Longitudinal changes of structural connectivity in traumatic axonal injury

J. Y. Wang, K. Bakhadirov, H. Abdi, M. D. Devous, C. D. Marquez De La Plata, C. Moore, C. J. Madden, R. Diaz-Arrastia

Research output: Contribution to journalArticle

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Abstract

Objectives: To identify structural connectivity change occurring during the first 6 months after traumatic brain injury and to evaluate the utility of diffusion tensor tractography for predicting long-term outcome. Methods: The participants were 28 patients with mild to severe traumatic axonal injury and 20 age- and sex-matched healthy control subjects. Neuroimaging was obtained 0-9 days postinjury for acute scans and 6-14 months postinjury for chronic scans. Long-term outcome was evaluated on the day of the chronic scan. Twenty-eight fiber regions of 9 major white matter structures were reconstructed, and reliable tractography measurements were determined and used. Results: Although most (23 of 28) patients had severe brain injury, their long-term outcome ranged from good recovery (16 patients) to moderately (5 patients) and severely disabled (7 patients). In concordance with the diverse outcome, the white matter change in patients was heterogeneous, ranging from improved structural connectivity, through no change, to deteriorated connectivity. At the group level, all 9 fiber tracts deteriorated significantly with 7 (corpus callosum, cingulum, angular bundle, cerebral peduncular fibers, uncinate fasciculus, and inferior longitudinal and fronto-occipital fasciculi) showing structural damage acutely and 2 (fornix body and left arcuate fasciculus) chronically. Importantly, the amount of change in tractography measurements correlated with patients' long-term outcome. Acute tractography measurements were able to predict patients' learning and memory performance; chronic measurements also determined performance on processing speed and executive function. Conclusions: Diffusion tensor tractography is a valuable tool for identifying structural connectivity changes occurring between the acute and chronic stages of traumatic brain injury and for predicting patients' long-term outcome.

Original languageEnglish (US)
Pages (from-to)818-826
Number of pages9
JournalNeurology
Volume77
Issue number9
DOIs
StatePublished - Aug 30 2011

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Wounds and Injuries
Diffusion Tensor Imaging
Connectivity
Corpus Callosum
Executive Function
Neuroimaging
Brain Injuries
Healthy Volunteers
Learning
Fiber
Traumatic Brain Injury
White Matter

ASJC Scopus subject areas

  • Clinical Neurology
  • Arts and Humanities (miscellaneous)

Cite this

Wang, J. Y., Bakhadirov, K., Abdi, H., Devous, M. D., Marquez De La Plata, C. D., Moore, C., ... Diaz-Arrastia, R. (2011). Longitudinal changes of structural connectivity in traumatic axonal injury. Neurology, 77(9), 818-826. https://doi.org/10.1212/WNL.0b013e31822c61d7

Longitudinal changes of structural connectivity in traumatic axonal injury. / Wang, J. Y.; Bakhadirov, K.; Abdi, H.; Devous, M. D.; Marquez De La Plata, C. D.; Moore, C.; Madden, C. J.; Diaz-Arrastia, R.

In: Neurology, Vol. 77, No. 9, 30.08.2011, p. 818-826.

Research output: Contribution to journalArticle

Wang, JY, Bakhadirov, K, Abdi, H, Devous, MD, Marquez De La Plata, CD, Moore, C, Madden, CJ & Diaz-Arrastia, R 2011, 'Longitudinal changes of structural connectivity in traumatic axonal injury', Neurology, vol. 77, no. 9, pp. 818-826. https://doi.org/10.1212/WNL.0b013e31822c61d7
Wang JY, Bakhadirov K, Abdi H, Devous MD, Marquez De La Plata CD, Moore C et al. Longitudinal changes of structural connectivity in traumatic axonal injury. Neurology. 2011 Aug 30;77(9):818-826. https://doi.org/10.1212/WNL.0b013e31822c61d7
Wang, J. Y. ; Bakhadirov, K. ; Abdi, H. ; Devous, M. D. ; Marquez De La Plata, C. D. ; Moore, C. ; Madden, C. J. ; Diaz-Arrastia, R. / Longitudinal changes of structural connectivity in traumatic axonal injury. In: Neurology. 2011 ; Vol. 77, No. 9. pp. 818-826.
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