TY - JOUR
T1 - Longitudinal examination of fellow-eye vascular anomalies in coats’ disease with widefield fluorescein angiography
T2 - A multicenter study
AU - Jeng-Miller, Karen W.
AU - Soomro, Taha
AU - Scott, Nathan L.
AU - Rao, Prethy
AU - Marlow, Elizabeth
AU - Chang, Emmanuel Y.
AU - Ells, Anna
AU - Chau, Felix
AU - Nudleman, Eric
AU - Calvo, Charles M.
AU - Patel, Nish
AU - Schwartz, Roy
AU - Cernichiaro-Espinosa, Linda A.
AU - Montoya, Alexandrea Gabrielle
AU - Goldstein, Jessica
AU - Harper, C. Armitage
AU - Baumal, Caroline R.
AU - Hartnett, Mary Elizabeth
AU - Harbour, J. William
AU - Besirli, Cagri G.
AU - Gupta, Mrinali P.
AU - Chan, R. V.Paul
AU - Drenser, Kimberly A.
AU - Capone, Antonio
AU - Murray, Timothy G.
AU - Mukai, Shizuo
AU - Trese, Michael T.
AU - Berrocal, Audina M.
AU - Wong, Sui Chien
AU - Yonekawa, Yoshihiro
N1 - Publisher Copyright:
© 2019 Slack Incorporated. All rights reserved.
PY - 2019
Y1 - 2019
N2 - BACKGROUND AND OBJECTIVE: Retinovascular anomalies in the fellow eyes of patients with Coats’ disease have been described, but the clinical significance is unknown, as well as whether these lesions progress over time. PATIENTS AND METHODS: This is an international, multicenter, retrospective, observational cohort study of fellow-eye abnormalities on widefield fluorescein angiography in patients with Coats’ disease. RESULTS: Three hundred fifty eyes of 175 patients with Coats’ disease were analyzed. A total of 33 patients (18.8%) demonstrated abnormal fellow-eye findings: 14 (42.4%) telangiectasias, 18 (54.5%) aneurysms, six (18.2%) segmental non-perfusion, six (18.2%) leakage, and two (6.0%) vascular tortuosity. All eyes were asymptomatic, and none of the lesions progressed over time. There was no association between fellow-eye findings with severity of Coats’ disease (P = .16), patient age (P = .16), or presence of systemic vascular disease (P = .16). CONCLUSIONS: The vascular abnormalities in fellow eyes of patients with Coats’ disease did not progress over time. Observation is a reasonable initial management strategy.
AB - BACKGROUND AND OBJECTIVE: Retinovascular anomalies in the fellow eyes of patients with Coats’ disease have been described, but the clinical significance is unknown, as well as whether these lesions progress over time. PATIENTS AND METHODS: This is an international, multicenter, retrospective, observational cohort study of fellow-eye abnormalities on widefield fluorescein angiography in patients with Coats’ disease. RESULTS: Three hundred fifty eyes of 175 patients with Coats’ disease were analyzed. A total of 33 patients (18.8%) demonstrated abnormal fellow-eye findings: 14 (42.4%) telangiectasias, 18 (54.5%) aneurysms, six (18.2%) segmental non-perfusion, six (18.2%) leakage, and two (6.0%) vascular tortuosity. All eyes were asymptomatic, and none of the lesions progressed over time. There was no association between fellow-eye findings with severity of Coats’ disease (P = .16), patient age (P = .16), or presence of systemic vascular disease (P = .16). CONCLUSIONS: The vascular abnormalities in fellow eyes of patients with Coats’ disease did not progress over time. Observation is a reasonable initial management strategy.
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U2 - 10.3928/23258160-20190401-04
DO - 10.3928/23258160-20190401-04
M3 - Article
C2 - 30998243
AN - SCOPUS:85065098864
SN - 2325-8160
VL - 50
SP - 221
EP - 227
JO - Ophthalmic Surgery Lasers and Imaging Retina
JF - Ophthalmic Surgery Lasers and Imaging Retina
IS - 4
ER -