Loracarbef concentrations in middle ear fluid

H. Kusmiesz, S. Shelton, O. Brown, S. Manning, J. D. Nelson

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

Loracarbef concentrations in plasma and middle ear fluid (MEF) were measured in specimens obtained approximately 2 h after doses of 7.5 or 15 mg/kg. The mean ± standard deviation concentrations in MEF were 2.0 ± 2.6 mg/liter (48% of the concentration in plasma) after the smaller dose and 3.9 ± 2.6 mg/liter (42% of the concentration in plasma) after the larger dose. With the larger dose, the concentrations in MEF were greater than the MIC for 90% of strains of the usual pathogens of acute otitis media tested in 16 of 17 specimens.

Original languageEnglish (US)
Pages (from-to)2030-2031
Number of pages2
JournalAntimicrobial agents and chemotherapy
Volume34
Issue number10
DOIs
StatePublished - Jan 1 1990

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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