Loss of brain-derived neurotrophic factor-dependent neural crest-derived sensory neurons in neurotrophin-4 mutant mice

Daniel J. Liebl, Laura J. Klesse, Lino Tessarollo, Todd Wohlman, Luis F. Parada

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

Peripheral ganglion neurons confer sensory information including touch, pain, temperature, and proprioception. Sensory modality is linked to specific neurotrophin (NTF) requirements. NT-3 supports survival of neurons that differentiate primarily into proprioceptors whereas nerve growth factor and brain-derived neurotrophic factor (BDNF) support subpopulations that transmit nociception and mechanoreception, respectively. We examined sensory neurons of gene-targeted mouse mutants at the NT-4, BDNF, NT-3, and TrkA loci. We show that NT-4 functions early in gangliogenesis, upstream of BDNF. In the absence of NT-4 function, BDNF-dependent, TrkB-expressing neurons fail to appear. The results are consistent with the model that precursor cells intended to become BDNFdependent mechanoreceptors instead differentiate into NT-3-dependent proprioceptive neurons.

Original languageEnglish (US)
Pages (from-to)2297-2302
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume97
Issue number5
DOIs
StatePublished - Feb 29 2000

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Neural Crest
Brain-Derived Neurotrophic Factor
Sensory Receptor Cells
Neurons
Proprioception
Mechanoreceptors
Nociception
Nerve Growth Factors
Touch
Nerve Growth Factor
Ganglia
Pain
Temperature
neurotrophin 4
Genes

ASJC Scopus subject areas

  • Genetics
  • General

Cite this

Loss of brain-derived neurotrophic factor-dependent neural crest-derived sensory neurons in neurotrophin-4 mutant mice. / Liebl, Daniel J.; Klesse, Laura J.; Tessarollo, Lino; Wohlman, Todd; Parada, Luis F.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 97, No. 5, 29.02.2000, p. 2297-2302.

Research output: Contribution to journalArticle

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