TY - JOUR
T1 - Loss of CD127 expression defines an expansion of effector CD8+ T cells in HIV-infected individuals
AU - Paiardini, Mirko
AU - Cervasi, Barbara
AU - Albrecht, Helmut
AU - Muthukumar, Alagarraju
AU - Dunham, Richard
AU - Gordon, Shari
AU - Radziewicz, Henry
AU - Piedimonte, Giuseppe
AU - Magnani, Mauro
AU - Montroni, Maria
AU - Kaech, Susan M.
AU - Weintrob, Amy
AU - Altman, John B.
AU - Sodora, Donald L.
AU - Feinberg, Mark B.
AU - Silvestri, Guido
PY - 2005/3/1
Y1 - 2005/3/1
N2 - The immunodeficiency that follows HIV infection is related to the virus-mediated killing of infected CD4+ T cells, the chronic activation of the immune system, and the impairment of T cell production. In this study we show that in HIV-infected individuals the loss of IL-7R (CD127) expression defines the expansion of a subset of CD8+ T cells, specific for HIV as well as other Ags, that show phenotypic (i.e., loss of CCR7 and CD62 ligand expression with enrichment in activated and/or proliferating cells) as well as functional (i.e., production of IFN-γ, but not IL-2, decreased ex vivo proliferative potential and increased susceptibility to apoptosis) features of effector T cells. Importantly, in HIV-infected individuals the levels of CD8+CD127- T cells are directly correlated with the main markers of disease progression (i.e., plasma viremia and CD4+ T cell depletion) as well as with the indices of overall T cell activation. In all, these results identify the expansion of CD8 +CD127- effector-like T cells as a novel feature of the HIV-associated immune perturbation. Further studies are thus warranted to determine whether measurements of CD127 expression on CD8+ T cells may be useful in the clinical management of HIV-infected individuals.
AB - The immunodeficiency that follows HIV infection is related to the virus-mediated killing of infected CD4+ T cells, the chronic activation of the immune system, and the impairment of T cell production. In this study we show that in HIV-infected individuals the loss of IL-7R (CD127) expression defines the expansion of a subset of CD8+ T cells, specific for HIV as well as other Ags, that show phenotypic (i.e., loss of CCR7 and CD62 ligand expression with enrichment in activated and/or proliferating cells) as well as functional (i.e., production of IFN-γ, but not IL-2, decreased ex vivo proliferative potential and increased susceptibility to apoptosis) features of effector T cells. Importantly, in HIV-infected individuals the levels of CD8+CD127- T cells are directly correlated with the main markers of disease progression (i.e., plasma viremia and CD4+ T cell depletion) as well as with the indices of overall T cell activation. In all, these results identify the expansion of CD8 +CD127- effector-like T cells as a novel feature of the HIV-associated immune perturbation. Further studies are thus warranted to determine whether measurements of CD127 expression on CD8+ T cells may be useful in the clinical management of HIV-infected individuals.
UR - http://www.scopus.com/inward/record.url?scp=20044382810&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=20044382810&partnerID=8YFLogxK
U2 - 10.4049/jimmunol.174.5.2900
DO - 10.4049/jimmunol.174.5.2900
M3 - Article
C2 - 15728501
AN - SCOPUS:20044382810
SN - 0022-1767
VL - 174
SP - 2900
EP - 2909
JO - Journal of Immunology
JF - Journal of Immunology
IS - 5
ER -