Loss of proteins regulating synaptic plasticity in normal aging of the human brain and in Alzheimer disease

Kimmo Hatanpää, Krystyna R. Isaacs, Tomoaki Shirao, Daniel R. Brady, Stanley I. Rapoport

Research output: Contribution to journalArticle

144 Citations (Scopus)

Abstract

Recent studies suggest that the cognitive impairment associated with normal aging is due to neuronal dysfunction rather than to loss of neurons or synapses. To characterize this dysfunction, molecular indices of neuronal function were quantified in autopsy samples of cerebral cortex. During normal aging, the most dramatic decline was found in levels of synaptic proteins involved in structural plasticity (remodeling) of axons and dendrites. Alzheimer disease, the most common cause of dementia in the elderly, was associated with an additional 81% decrease in levels of drebrin, a protein regulating postsynaptic plasticity. Disturbed mechanisms of plasticity may contribute to cognitive dysfunction during aging and in Alzheimer disease.

Original languageEnglish (US)
Pages (from-to)637-643
Number of pages7
JournalJournal of Neuropathology and Experimental Neurology
Volume58
Issue number6
StatePublished - 1999

Fingerprint

Neuronal Plasticity
Alzheimer Disease
Brain
Dendrites
Cerebral Cortex
Synapses
Axons
Dementia
Autopsy
Proteins
Neurons
Cognitive Dysfunction
drebrins

Keywords

  • Cytochrome oxidase
  • Drebrin
  • Energy metabolism
  • GAP-43
  • Neuron specific-enolase
  • Synaptophysin
  • β-tubulin

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Neuroscience(all)

Cite this

Loss of proteins regulating synaptic plasticity in normal aging of the human brain and in Alzheimer disease. / Hatanpää, Kimmo; Isaacs, Krystyna R.; Shirao, Tomoaki; Brady, Daniel R.; Rapoport, Stanley I.

In: Journal of Neuropathology and Experimental Neurology, Vol. 58, No. 6, 1999, p. 637-643.

Research output: Contribution to journalArticle

Hatanpää, Kimmo ; Isaacs, Krystyna R. ; Shirao, Tomoaki ; Brady, Daniel R. ; Rapoport, Stanley I. / Loss of proteins regulating synaptic plasticity in normal aging of the human brain and in Alzheimer disease. In: Journal of Neuropathology and Experimental Neurology. 1999 ; Vol. 58, No. 6. pp. 637-643.
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