Lost after translation: Post-translational modifications by bacterial type III effectors

Dor Salomon, Kim Orth

Research output: Contribution to journalReview articlepeer-review

6 Scopus citations

Abstract

Many Gram-negative bacterial pathogens use the type III secretion system to deliver effector proteins into host cells. These effectors use various mechanisms to exploit host processes to the advantage of the pathogen. A large group of effectors use post-translational modifications, either reversible or irreversible, to manipulate host proteins, and while most of these mechanisms mimic eukaryotic activities, others appear to be unique biochemical functions. Deciphering such mechanisms and identifying the host targets of these effectors sheds light on eukaryotic signaling pathways and immune responses.

Original languageEnglish (US)
Pages (from-to)213-220
Number of pages8
JournalCurrent Opinion in Microbiology
Volume16
Issue number2
DOIs
StatePublished - Apr 1 2013

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)
  • Infectious Diseases

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