Low body mass index is associated with increased waitlist mortality among children listed for heart transplant

Ryan R Davies, Shylah Haldeman, Michael A. McCulloch, Samuel S. Gidding, Christian Pizarro

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Background In adults, low body mass index (BMI) and high BMI have been associated with increased mortality after heart transplantation. Studies of BMI in children with heart failure have had inconsistent results. Methods The United Network for Organ Sharing database has 4,035 listings for primary, isolated heart transplant in patients 3 to 18 years old (1995-2012). BMI percentile-for-age (BMI%) was calculated, and patients were stratified based on BMI% into 4 groups: underweight (BMI% <5, n = 701 [17.4%]), normal weight (BMI% 5-84, n = 2,321 [57.5%]), overweight (BMI% 85-94, n = 440 [10.9%]), or obese (BMI% ≥95, n = 573 [14.2%]). Outcomes of patients on the waitlist and after transplantation were assessed. Results Unadjusted early waitlist mortality was highest in underweight patients (16.7%) compared with normal-weight (11.4%), overweight (10.9%), and obese (12.9%) patients (p = 0.04). In multivariable analysis, underweight patients had elevated risk-adjusted waitlist mortality (odds ratio = 1.4, 95% confidence interval = 1.0-2.2). Unadjusted post-transplant mortality did not differ across BMI% groups (underweight, 5.7%; normal weight, 5.4%; overweight, 5.5%; obese, 5.8%), but obese patients had borderline higher risk-adjusted post-transplant mortality (odds ratio = 1.7, 95% confidence interval = 1.0-3.0). Change in BMI% while waiting did not affect post-transplant mortality. Conclusions Children listed for heart transplant are commonly either underweight or obese. Underweight patients have high risk-adjusted mortality before transplantation, whereas obese patients have borderline higher adjusted post-transplant mortality.

Original languageEnglish (US)
Pages (from-to)1462-1470
Number of pages9
JournalJournal of Heart and Lung Transplantation
Volume34
Issue number11
DOIs
StatePublished - Nov 1 2015

Fingerprint

Child Mortality
Body Mass Index
Transplants
Thinness
Mortality
Weights and Measures
Transplantation
Odds Ratio
Confidence Intervals
Heart Transplantation
Heart Failure

Keywords

  • cardiac transplantation
  • obesity
  • outcomes
  • pediatrics
  • survival analysis

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine
  • Transplantation

Cite this

Low body mass index is associated with increased waitlist mortality among children listed for heart transplant. / Davies, Ryan R; Haldeman, Shylah; McCulloch, Michael A.; Gidding, Samuel S.; Pizarro, Christian.

In: Journal of Heart and Lung Transplantation, Vol. 34, No. 11, 01.11.2015, p. 1462-1470.

Research output: Contribution to journalArticle

Davies, Ryan R ; Haldeman, Shylah ; McCulloch, Michael A. ; Gidding, Samuel S. ; Pizarro, Christian. / Low body mass index is associated with increased waitlist mortality among children listed for heart transplant. In: Journal of Heart and Lung Transplantation. 2015 ; Vol. 34, No. 11. pp. 1462-1470.
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abstract = "Background In adults, low body mass index (BMI) and high BMI have been associated with increased mortality after heart transplantation. Studies of BMI in children with heart failure have had inconsistent results. Methods The United Network for Organ Sharing database has 4,035 listings for primary, isolated heart transplant in patients 3 to 18 years old (1995-2012). BMI percentile-for-age (BMI{\%}) was calculated, and patients were stratified based on BMI{\%} into 4 groups: underweight (BMI{\%} <5, n = 701 [17.4{\%}]), normal weight (BMI{\%} 5-84, n = 2,321 [57.5{\%}]), overweight (BMI{\%} 85-94, n = 440 [10.9{\%}]), or obese (BMI{\%} ≥95, n = 573 [14.2{\%}]). Outcomes of patients on the waitlist and after transplantation were assessed. Results Unadjusted early waitlist mortality was highest in underweight patients (16.7{\%}) compared with normal-weight (11.4{\%}), overweight (10.9{\%}), and obese (12.9{\%}) patients (p = 0.04). In multivariable analysis, underweight patients had elevated risk-adjusted waitlist mortality (odds ratio = 1.4, 95{\%} confidence interval = 1.0-2.2). Unadjusted post-transplant mortality did not differ across BMI{\%} groups (underweight, 5.7{\%}; normal weight, 5.4{\%}; overweight, 5.5{\%}; obese, 5.8{\%}), but obese patients had borderline higher risk-adjusted post-transplant mortality (odds ratio = 1.7, 95{\%} confidence interval = 1.0-3.0). Change in BMI{\%} while waiting did not affect post-transplant mortality. Conclusions Children listed for heart transplant are commonly either underweight or obese. Underweight patients have high risk-adjusted mortality before transplantation, whereas obese patients have borderline higher adjusted post-transplant mortality.",
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T1 - Low body mass index is associated with increased waitlist mortality among children listed for heart transplant

AU - Davies, Ryan R

AU - Haldeman, Shylah

AU - McCulloch, Michael A.

AU - Gidding, Samuel S.

AU - Pizarro, Christian

PY - 2015/11/1

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N2 - Background In adults, low body mass index (BMI) and high BMI have been associated with increased mortality after heart transplantation. Studies of BMI in children with heart failure have had inconsistent results. Methods The United Network for Organ Sharing database has 4,035 listings for primary, isolated heart transplant in patients 3 to 18 years old (1995-2012). BMI percentile-for-age (BMI%) was calculated, and patients were stratified based on BMI% into 4 groups: underweight (BMI% <5, n = 701 [17.4%]), normal weight (BMI% 5-84, n = 2,321 [57.5%]), overweight (BMI% 85-94, n = 440 [10.9%]), or obese (BMI% ≥95, n = 573 [14.2%]). Outcomes of patients on the waitlist and after transplantation were assessed. Results Unadjusted early waitlist mortality was highest in underweight patients (16.7%) compared with normal-weight (11.4%), overweight (10.9%), and obese (12.9%) patients (p = 0.04). In multivariable analysis, underweight patients had elevated risk-adjusted waitlist mortality (odds ratio = 1.4, 95% confidence interval = 1.0-2.2). Unadjusted post-transplant mortality did not differ across BMI% groups (underweight, 5.7%; normal weight, 5.4%; overweight, 5.5%; obese, 5.8%), but obese patients had borderline higher risk-adjusted post-transplant mortality (odds ratio = 1.7, 95% confidence interval = 1.0-3.0). Change in BMI% while waiting did not affect post-transplant mortality. Conclusions Children listed for heart transplant are commonly either underweight or obese. Underweight patients have high risk-adjusted mortality before transplantation, whereas obese patients have borderline higher adjusted post-transplant mortality.

AB - Background In adults, low body mass index (BMI) and high BMI have been associated with increased mortality after heart transplantation. Studies of BMI in children with heart failure have had inconsistent results. Methods The United Network for Organ Sharing database has 4,035 listings for primary, isolated heart transplant in patients 3 to 18 years old (1995-2012). BMI percentile-for-age (BMI%) was calculated, and patients were stratified based on BMI% into 4 groups: underweight (BMI% <5, n = 701 [17.4%]), normal weight (BMI% 5-84, n = 2,321 [57.5%]), overweight (BMI% 85-94, n = 440 [10.9%]), or obese (BMI% ≥95, n = 573 [14.2%]). Outcomes of patients on the waitlist and after transplantation were assessed. Results Unadjusted early waitlist mortality was highest in underweight patients (16.7%) compared with normal-weight (11.4%), overweight (10.9%), and obese (12.9%) patients (p = 0.04). In multivariable analysis, underweight patients had elevated risk-adjusted waitlist mortality (odds ratio = 1.4, 95% confidence interval = 1.0-2.2). Unadjusted post-transplant mortality did not differ across BMI% groups (underweight, 5.7%; normal weight, 5.4%; overweight, 5.5%; obese, 5.8%), but obese patients had borderline higher risk-adjusted post-transplant mortality (odds ratio = 1.7, 95% confidence interval = 1.0-3.0). Change in BMI% while waiting did not affect post-transplant mortality. Conclusions Children listed for heart transplant are commonly either underweight or obese. Underweight patients have high risk-adjusted mortality before transplantation, whereas obese patients have borderline higher adjusted post-transplant mortality.

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KW - outcomes

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