TY - JOUR
T1 - Low Fitness in Midlife
T2 - A Novel Therapeutic Target for Heart Failure with Preserved Ejection Fraction Prevention
AU - Pandey, Ambarish
AU - Darden, Douglas
AU - Berry, Jarett D.
N1 - Funding Information:
Dr. Berry receives funding from (1) the Dedman Family Scholar in Clinical Care endowment at University of Texas Southwestern Medical Center and (2) grant 14SFRN20740000 from the American Heart Association Prevention Network. The corresponding author had full access to all data in the study and had final responsibility for the decision to submit for publication. All authors have read and agree to the manuscript as written.
Publisher Copyright:
© 2015 Elsevier Inc.
Copyright:
Copyright 2015 Elsevier B.V., All rights reserved.
PY - 2015/7/1
Y1 - 2015/7/1
N2 - Heart failure (HF) with preserved ejection fraction (HFpEF) is common and recalcitrant to any medical therapy, highlighting the need for novel strategies focused on its prevention. Recent studies have shown that low cardiorespiratory fitness (CRF) in middle age identifies a subgroup of individuals at particularly high risk for HF, particularly HFpEF. These findings suggest that low CRF in middle age represents an upstream marker for late-life HFpEF. Furthermore, evidence from recent epidemiological studies suggests that low CRF associated risk for HFpEF appears to be modifiable with improvement in CRF. The primary objective of this review is to provide an overview of the potential mechanisms through which exercise training and improvement in CRF may protect against the transition from a low fit stage to clinical HFpEF among at-risk sedentary, middle-age adults.
AB - Heart failure (HF) with preserved ejection fraction (HFpEF) is common and recalcitrant to any medical therapy, highlighting the need for novel strategies focused on its prevention. Recent studies have shown that low cardiorespiratory fitness (CRF) in middle age identifies a subgroup of individuals at particularly high risk for HF, particularly HFpEF. These findings suggest that low CRF in middle age represents an upstream marker for late-life HFpEF. Furthermore, evidence from recent epidemiological studies suggests that low CRF associated risk for HFpEF appears to be modifiable with improvement in CRF. The primary objective of this review is to provide an overview of the potential mechanisms through which exercise training and improvement in CRF may protect against the transition from a low fit stage to clinical HFpEF among at-risk sedentary, middle-age adults.
KW - Cardiorespiratory fitness
KW - Exercise training
KW - Heart failure with preserved ejection fraction
UR - http://www.scopus.com/inward/record.url?scp=84937539526&partnerID=8YFLogxK
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U2 - 10.1016/j.pcad.2015.05.007
DO - 10.1016/j.pcad.2015.05.007
M3 - Article
C2 - 25982216
AN - SCOPUS:84937539526
SN - 0033-0620
VL - 58
SP - 87
EP - 93
JO - Progress in Cardiovascular Diseases
JF - Progress in Cardiovascular Diseases
IS - 1
ER -