TY - JOUR
T1 - Low flow-mediated constriction
T2 - Prevalence, impact and physiological determinant
AU - Harrison, Michelle
AU - Parkhurst, Kristin
AU - Tarumi, Takashi
AU - Lin, Hsin Fu
AU - Tanaka, Hirofumi
PY - 2011/9
Y1 - 2011/9
N2 - Flow-mediated dilation (FMD) is a surrogate marker for endothelial function. In the FMD procedure, arterial response during cuff inflation is not taken into consideration yet studies have demonstrated vasoconstriction, vasodilation and no change in the brachial artery during cuff inflation. The term low flow-mediated constriction (L-FMC) has been introduced to describe the vasoconstriction that occurs in some individuals during inflation of the cuff. The aims of this study were to examine (i) whether brachial artery response during cuff inflation differed in a population with varied coronary artery disease (CAD) risk factor profiles, (ii) the impact of this response on the subsequent calculation of FMD and (iii) the role of arterial stiffness in this variable response. L-FMC, 'traditional' FMD and 'modified' FMD, which accounts for brachial artery response during cuff inflation, were studied in a total of 46 subjects varying in risk factor profiles for coronary artery disease. During cuff inflation, brachial artery responses varied widely from -5·6% (vasoconstriction) to 5·0% (vasodilation). When subjects were divided into healthy versus multiple risk factors (n=34), L-FMC and FMD were not different between the groups but modified FMD was significantly different (P=0·02). L-FMC was modestly but significantly associated with FMD (r=0·41) and positively correlated with brachial artery pulse wave velocity (r=0·30). Our results indicate that brachial artery responses to inflation of the cuff are very variable and are associated with arterial stiffness and that accounting for so-called L-FMC may provide a more comprehensive assessment of endothelial vasodilatory function.
AB - Flow-mediated dilation (FMD) is a surrogate marker for endothelial function. In the FMD procedure, arterial response during cuff inflation is not taken into consideration yet studies have demonstrated vasoconstriction, vasodilation and no change in the brachial artery during cuff inflation. The term low flow-mediated constriction (L-FMC) has been introduced to describe the vasoconstriction that occurs in some individuals during inflation of the cuff. The aims of this study were to examine (i) whether brachial artery response during cuff inflation differed in a population with varied coronary artery disease (CAD) risk factor profiles, (ii) the impact of this response on the subsequent calculation of FMD and (iii) the role of arterial stiffness in this variable response. L-FMC, 'traditional' FMD and 'modified' FMD, which accounts for brachial artery response during cuff inflation, were studied in a total of 46 subjects varying in risk factor profiles for coronary artery disease. During cuff inflation, brachial artery responses varied widely from -5·6% (vasoconstriction) to 5·0% (vasodilation). When subjects were divided into healthy versus multiple risk factors (n=34), L-FMC and FMD were not different between the groups but modified FMD was significantly different (P=0·02). L-FMC was modestly but significantly associated with FMD (r=0·41) and positively correlated with brachial artery pulse wave velocity (r=0·30). Our results indicate that brachial artery responses to inflation of the cuff are very variable and are associated with arterial stiffness and that accounting for so-called L-FMC may provide a more comprehensive assessment of endothelial vasodilatory function.
KW - Arterial reactivity
KW - Arterial stiffness
KW - Cardiovascular function
KW - Endothelial function
KW - Flow-mediated dilation
UR - http://www.scopus.com/inward/record.url?scp=79960564293&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79960564293&partnerID=8YFLogxK
U2 - 10.1111/j.1475-097X.2011.01032.x
DO - 10.1111/j.1475-097X.2011.01032.x
M3 - Article
C2 - 21771260
AN - SCOPUS:79960564293
SN - 1475-0961
VL - 31
SP - 394
EP - 398
JO - Clinical Physiology and Functional Imaging
JF - Clinical Physiology and Functional Imaging
IS - 5
ER -