Low flow-mediated constriction

Prevalence, impact and physiological determinant

Michelle Harrison, Kristin Parkhurst, Takashi Tarumi, Hsin Fu Lin, Hirofumi Tanaka

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Flow-mediated dilation (FMD) is a surrogate marker for endothelial function. In the FMD procedure, arterial response during cuff inflation is not taken into consideration yet studies have demonstrated vasoconstriction, vasodilation and no change in the brachial artery during cuff inflation. The term low flow-mediated constriction (L-FMC) has been introduced to describe the vasoconstriction that occurs in some individuals during inflation of the cuff. The aims of this study were to examine (i) whether brachial artery response during cuff inflation differed in a population with varied coronary artery disease (CAD) risk factor profiles, (ii) the impact of this response on the subsequent calculation of FMD and (iii) the role of arterial stiffness in this variable response. L-FMC, 'traditional' FMD and 'modified' FMD, which accounts for brachial artery response during cuff inflation, were studied in a total of 46 subjects varying in risk factor profiles for coronary artery disease. During cuff inflation, brachial artery responses varied widely from -5·6% (vasoconstriction) to 5·0% (vasodilation). When subjects were divided into healthy versus multiple risk factors (n=34), L-FMC and FMD were not different between the groups but modified FMD was significantly different (P=0·02). L-FMC was modestly but significantly associated with FMD (r=0·41) and positively correlated with brachial artery pulse wave velocity (r=0·30). Our results indicate that brachial artery responses to inflation of the cuff are very variable and are associated with arterial stiffness and that accounting for so-called L-FMC may provide a more comprehensive assessment of endothelial vasodilatory function.

Original languageEnglish (US)
Pages (from-to)394-398
Number of pages5
JournalClinical Physiology and Functional Imaging
Volume31
Issue number5
DOIs
StatePublished - Sep 1 2011

Fingerprint

Constriction
Economic Inflation
Brachial Artery
Dilatation
Vasoconstriction
Vascular Stiffness
Vasodilation
Coronary Artery Disease
Pulse Wave Analysis
Biomarkers
Population

Keywords

  • Arterial reactivity
  • Arterial stiffness
  • Cardiovascular function
  • Endothelial function
  • Flow-mediated dilation

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

Cite this

Low flow-mediated constriction : Prevalence, impact and physiological determinant. / Harrison, Michelle; Parkhurst, Kristin; Tarumi, Takashi; Lin, Hsin Fu; Tanaka, Hirofumi.

In: Clinical Physiology and Functional Imaging, Vol. 31, No. 5, 01.09.2011, p. 394-398.

Research output: Contribution to journalArticle

Harrison, Michelle ; Parkhurst, Kristin ; Tarumi, Takashi ; Lin, Hsin Fu ; Tanaka, Hirofumi. / Low flow-mediated constriction : Prevalence, impact and physiological determinant. In: Clinical Physiology and Functional Imaging. 2011 ; Vol. 31, No. 5. pp. 394-398.
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