Low-grade astrocytoma: A decade of experience at St. Jude Children's Research Hospital

Amar Gajjar, Robert A. Sanford, Richard Heideman, Jesse J. Jenkins, Andrew Walter, Yulan Li, James W. Langston, Michael Muhlbauer, James M. Boyett, Larry E. Kun

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Abstract

Purpose: To evaluate the impact of primary tumor site, age at diagnosis, extent of resection, and histology on progression-free survival (PFS) in pediatric low-grade astrocytoma. Patients and Methods: Medical, pathologic, and imaging information were reviewed for 142 children (ages 2 months to 19 years) with low-grade astrocytoma treated between January 1984 and July 1994. Gross total resection (GTR) was attempted for cerebellar and cerebral hemisphere tumors, with biopsy or less aggressive resection used predominantly for tumors in other sites. Surgery was followed by observation in 107 cases, radiation therapy in 31, and chemotherapy in four. Results: The overall survival rate was 90% ± 3% (SE) at 4 years. PFS was significantly better for patients with cerebellar and cerebral hemisphere tumors (n = 75) than those with tumors in all other sites (P = .0006). Within the former group, there was no significant difference in PFS for patients in whom GTR was achieved versus those with incomplete resections (4-year estimates, 89% and 77%, respectively). Histology (juvenile pilocytic v astrocytoma not otherwise specified [NOS]) was not related to PFS in an analysis that controlled for tumor site and patient age. Patients younger than 5 years at diagnosis had a significantly poorer PFS than older children, regardless of histology (P < .03) or tumor site (P < .002). Treatment for progressive/recurrent disease was effective in a majority of patients, but appeared more successful in patients with hemispheric than thalamic or hypothalamic tumors. Conclusion: The overall survival in this series of pediatric low-grade astrocytomas is excellent. Age at diagnosis and tumor location, but not histology, had a significant impact on PFS. Efforts to improve treatment outcome should focus on young patients (< 5 years) and on those with central midline tumors. The majority of patients with completely resected hemispheric tumors were monitored without further therapy, which supports attempted GTR of cerebral and cerebellar hemisphere low-grade astrocytoma.

Original languageEnglish (US)
Pages (from-to)2792-2799
Number of pages8
JournalJournal of Clinical Oncology
Volume15
Issue number8
DOIs
StatePublished - Jan 1 1997

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Astrocytoma
Disease-Free Survival
Research
Neoplasms
Histology
Cerebrum
Hypothalamic Neoplasms
Pediatrics
Diagnostic Imaging
Survival Analysis
Radiotherapy
Survival Rate
Observation
Biopsy
Drug Therapy
Survival

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Gajjar, A., Sanford, R. A., Heideman, R., Jenkins, J. J., Walter, A., Li, Y., ... Kun, L. E. (1997). Low-grade astrocytoma: A decade of experience at St. Jude Children's Research Hospital. Journal of Clinical Oncology, 15(8), 2792-2799. https://doi.org/10.1200/JCO.1997.15.8.2792

Low-grade astrocytoma : A decade of experience at St. Jude Children's Research Hospital. / Gajjar, Amar; Sanford, Robert A.; Heideman, Richard; Jenkins, Jesse J.; Walter, Andrew; Li, Yulan; Langston, James W.; Muhlbauer, Michael; Boyett, James M.; Kun, Larry E.

In: Journal of Clinical Oncology, Vol. 15, No. 8, 01.01.1997, p. 2792-2799.

Research output: Contribution to journalArticle

Gajjar, A, Sanford, RA, Heideman, R, Jenkins, JJ, Walter, A, Li, Y, Langston, JW, Muhlbauer, M, Boyett, JM & Kun, LE 1997, 'Low-grade astrocytoma: A decade of experience at St. Jude Children's Research Hospital', Journal of Clinical Oncology, vol. 15, no. 8, pp. 2792-2799. https://doi.org/10.1200/JCO.1997.15.8.2792
Gajjar, Amar ; Sanford, Robert A. ; Heideman, Richard ; Jenkins, Jesse J. ; Walter, Andrew ; Li, Yulan ; Langston, James W. ; Muhlbauer, Michael ; Boyett, James M. ; Kun, Larry E. / Low-grade astrocytoma : A decade of experience at St. Jude Children's Research Hospital. In: Journal of Clinical Oncology. 1997 ; Vol. 15, No. 8. pp. 2792-2799.
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abstract = "Purpose: To evaluate the impact of primary tumor site, age at diagnosis, extent of resection, and histology on progression-free survival (PFS) in pediatric low-grade astrocytoma. Patients and Methods: Medical, pathologic, and imaging information were reviewed for 142 children (ages 2 months to 19 years) with low-grade astrocytoma treated between January 1984 and July 1994. Gross total resection (GTR) was attempted for cerebellar and cerebral hemisphere tumors, with biopsy or less aggressive resection used predominantly for tumors in other sites. Surgery was followed by observation in 107 cases, radiation therapy in 31, and chemotherapy in four. Results: The overall survival rate was 90{\%} ± 3{\%} (SE) at 4 years. PFS was significantly better for patients with cerebellar and cerebral hemisphere tumors (n = 75) than those with tumors in all other sites (P = .0006). Within the former group, there was no significant difference in PFS for patients in whom GTR was achieved versus those with incomplete resections (4-year estimates, 89{\%} and 77{\%}, respectively). Histology (juvenile pilocytic v astrocytoma not otherwise specified [NOS]) was not related to PFS in an analysis that controlled for tumor site and patient age. Patients younger than 5 years at diagnosis had a significantly poorer PFS than older children, regardless of histology (P < .03) or tumor site (P < .002). Treatment for progressive/recurrent disease was effective in a majority of patients, but appeared more successful in patients with hemispheric than thalamic or hypothalamic tumors. Conclusion: The overall survival in this series of pediatric low-grade astrocytomas is excellent. Age at diagnosis and tumor location, but not histology, had a significant impact on PFS. Efforts to improve treatment outcome should focus on young patients (< 5 years) and on those with central midline tumors. The majority of patients with completely resected hemispheric tumors were monitored without further therapy, which supports attempted GTR of cerebral and cerebellar hemisphere low-grade astrocytoma.",
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AU - Li, Yulan

AU - Langston, James W.

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