TY - JOUR
T1 - Low-grade papillary adenocarcinoma of the palate
T2 - The significance of distinguishing it from polymorphous low-grade adenocarcinoma
AU - Hunter, Jacob B.
AU - Smith, Richard V.
AU - Brandwein-Gensler, Margaret
PY - 2008
Y1 - 2008
N2 - Low-grade papillary adenocarcinoma (LGPA) represents a relatively rare histological variant of polymorphous low-grade adenocarcinoma (PLGA). There has been a debate as to whether LGPA is associated with greater aggressive potential compared to PLGA; this is further obfuscated by the fact that diagnostic criteria for LGPA have not been well-defined. We believe that this is the first report of a patient with LGPA who developed metastases to the femur and scalp. We review the published evidence for classifying LGPA as distinct from PLGA. The weight of published data does support the idea that LGPA is oncologically distinct from LGPA. However, as uniform diagnostic criteria are lacking, we suggest a cut-off value of 10% or greater papillary formation as being necessary to separate LGPA from PLGA.
AB - Low-grade papillary adenocarcinoma (LGPA) represents a relatively rare histological variant of polymorphous low-grade adenocarcinoma (PLGA). There has been a debate as to whether LGPA is associated with greater aggressive potential compared to PLGA; this is further obfuscated by the fact that diagnostic criteria for LGPA have not been well-defined. We believe that this is the first report of a patient with LGPA who developed metastases to the femur and scalp. We review the published evidence for classifying LGPA as distinct from PLGA. The weight of published data does support the idea that LGPA is oncologically distinct from LGPA. However, as uniform diagnostic criteria are lacking, we suggest a cut-off value of 10% or greater papillary formation as being necessary to separate LGPA from PLGA.
KW - Low-grade papillary adenocarcinoma
KW - Oral salivary gland tumor
KW - Polymorphous low-grade adenocarcinoma
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U2 - 10.1007/s12105-008-0082-1
DO - 10.1007/s12105-008-0082-1
M3 - Review article
C2 - 20614302
AN - SCOPUS:77957326925
SN - 1936-055X
VL - 2
SP - 316
EP - 323
JO - Head and Neck Pathology
JF - Head and Neck Pathology
IS - 4
ER -