Low HDL predicts differential blood pressure effects from two weight-loss approaches: A secondary analysis of blood pressure from a randomized, clinical weight-loss trial

C. B. Turer, I. H. Bernstein, D. E. Edelman, W. S. Yancy

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Examining predictors of blood-pressure (BP) response to weight-loss diets might provide insight into mechanisms and help guide clinical care. We examined whether certain baseline patient characteristics (e.g. diet, medical history and laboratory tests) predicted BP response to two weight-loss diet approaches that differ in macronutrient content. One hundred and forty-six overweight adult outpatients were randomized to either a low-carbohydrate diet (N = 72) or orlistat plus a low-fat diet (N = 74) for 48 weeks. Predictors of BP reduction were evaluated using a structured approach and random effects regression models. Participants were 56% African-American, 72% male and 53 (±10) years-old. Of the variables considered, low baseline high-density lipoprotein (HDL) predicted greater reduction in BP in those patients who received the low-carbohydrate diet (p = 0.03 for systolic BP; p = 0.03 for diastolic BP and p = 0.02 for mean arterial pressure). A low HDL level may identify patients who will have greater BP improvement on a low-carbohydrate diet. Published 2011. This article is a U.S. Government work and is in the public domain in the USA.

Original languageEnglish (US)
Pages (from-to)375-378
Number of pages4
JournalDiabetes, Obesity and Metabolism
Volume14
Issue number4
DOIs
StatePublished - Apr 2012

Keywords

  • Clinical trial
  • Dietary intervention
  • Dyslipidaemia
  • Hypertension
  • Obesity therapy
  • Weight-loss therapy

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Fingerprint Dive into the research topics of 'Low HDL predicts differential blood pressure effects from two weight-loss approaches: A secondary analysis of blood pressure from a randomized, clinical weight-loss trial'. Together they form a unique fingerprint.

  • Cite this