Low prevalence of Helicobacter pylori infection among patients with inflammatory bowel disease

A. Sonnenberg, R. M. Genta

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

Background There is some preliminary evidence to suggest that patients with inflammatory bowel disease (IBD) are less frequently infected with Helicobacter pylori than the general population. Aim To examine whether the prevalence of Helicobacter pylori (H. pylori) is lower among IBD patients compared with non-IBD individuals based on results from surgical pathology. Methods From a database of surgical pathology reports, we recruited a sample of unique patients who underwent a same-day bidirectional gastrointestinal endoscopy with biopsies. Of the total 65 515 patients, 1061 served as cases with IBD and 64 451 as controls without IBD. The histological presence of H. pylori was correlated with the patients' demographic characteristics and histological presence of any oesophageal disease, Crohn's disease (CD), ulcerative colitis (UC) and indeterminate colitis (IND). Results were expressed as odds ratios (OR), using multivariate logistic regression to adjust for the cofounding influence of comorbidities and demographic characteristics. Results The presence of H. pylori was inversely associated with IBD, the adjusted OR and their 95% confidence intervals being 0.48 (0.27-0.79) for CD, 0.59 (0.39-0.84) for UC and 0.43 (0.15-0.95) for IND. In contradistinction, H. pylori-negative gastritis was positively associated with IBD, the adjusted OR being 11.06 (7.98-15.02) for CD, 2.25 (1.31-3.60) for UC and 6.91 (3.50-12.30) for IND. Conclusions Our study confirms an inverse association between H. pylori and IBD and a positive association between the H. pylori-negative gastritis and IBD. These relationships may open new avenues to study the pathogenesis of IBD.

Original languageEnglish (US)
Pages (from-to)469-476
Number of pages8
JournalAlimentary Pharmacology and Therapeutics
Volume35
Issue number4
DOIs
StatePublished - Feb 2012

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Helicobacter Infections
Inflammatory Bowel Diseases
Helicobacter pylori
Colitis
Ulcerative Colitis
Crohn Disease
Surgical Pathology
Odds Ratio
Gastritis
Demography
Esophageal Diseases
Gastrointestinal Endoscopy
Comorbidity
Logistic Models
Databases
Confidence Intervals
Biopsy

ASJC Scopus subject areas

  • Pharmacology (medical)

Cite this

Low prevalence of Helicobacter pylori infection among patients with inflammatory bowel disease. / Sonnenberg, A.; Genta, R. M.

In: Alimentary Pharmacology and Therapeutics, Vol. 35, No. 4, 02.2012, p. 469-476.

Research output: Contribution to journalArticle

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