Low serum vitamin D levels and recurrent inflammatory spinal cord disease

Maureen A. Mealy, Scott Newsome, Benjamin M. Greenberg, Dean Wingerchuk, Peter Calabresi, Michael Levy

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Background: Low 25-hydroxyvitaminDlevels have been associated with a higher risk of developing multiple sclerosis and increased relapse rates in patients with multiple sclerosis. As a sterol hormone involved in multiple immunologic pathways, vitamin D may play a role in preventing monophasic immune-mediated central nervous system attacks from developing into recurrent disease. Objective: To investigate the association between low serum vitamin D levels and recurrent spinal cord disease. Design, Setting, and Patients: We performed a retrospective analysis at Johns Hopkins Transverse Myelitis Center, Baltimore, Maryland, evaluating 25- hydroxyvitamin D levels in 77 patients with monophasic and recurrent inflammatory diseases of the spinal cord. Main Outcome Measure: Levels of 25-hydroxyvitamin D. Results: Vitamin D levels are significantly lower in patients who developed recurrent spinal cord disease, adjusting for season, age, sex, and race. Conclusions: This study provides a basis for a prospective trial of measuring 25-hydroxyvitaminDlevels in these patient populations and assessing the influence of vitamin D supplementation on the frequency of relapses in those with recurrent inflammatory spinal cord disease.

Original languageEnglish (US)
Pages (from-to)352-356
Number of pages5
JournalArchives of Neurology
Volume69
Issue number3
DOIs
StatePublished - Mar 2012

Fingerprint

Spinal Cord Diseases
Vitamin D
Serum
Multiple Sclerosis
Transverse Myelitis
Recurrence
Baltimore
Sterols
Central Nervous System
Outcome Assessment (Health Care)
Cord
Hormones
Population
25-hydroxyvitamin D
Relapse

ASJC Scopus subject areas

  • Clinical Neurology
  • Arts and Humanities (miscellaneous)

Cite this

Low serum vitamin D levels and recurrent inflammatory spinal cord disease. / Mealy, Maureen A.; Newsome, Scott; Greenberg, Benjamin M.; Wingerchuk, Dean; Calabresi, Peter; Levy, Michael.

In: Archives of Neurology, Vol. 69, No. 3, 03.2012, p. 352-356.

Research output: Contribution to journalArticle

Mealy, MA, Newsome, S, Greenberg, BM, Wingerchuk, D, Calabresi, P & Levy, M 2012, 'Low serum vitamin D levels and recurrent inflammatory spinal cord disease', Archives of Neurology, vol. 69, no. 3, pp. 352-356. https://doi.org/10.1001/archneurol.2011.1974
Mealy, Maureen A. ; Newsome, Scott ; Greenberg, Benjamin M. ; Wingerchuk, Dean ; Calabresi, Peter ; Levy, Michael. / Low serum vitamin D levels and recurrent inflammatory spinal cord disease. In: Archives of Neurology. 2012 ; Vol. 69, No. 3. pp. 352-356.
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