TY - JOUR
T1 - Low serum vitamin D levels and recurrent inflammatory spinal cord disease
AU - Mealy, Maureen A.
AU - Newsome, Scott
AU - Greenberg, Benjamin M.
AU - Wingerchuk, Dean
AU - Calabresi, Peter
AU - Levy, Michael
PY - 2012/3
Y1 - 2012/3
N2 - Background: Low 25-hydroxyvitaminDlevels have been associated with a higher risk of developing multiple sclerosis and increased relapse rates in patients with multiple sclerosis. As a sterol hormone involved in multiple immunologic pathways, vitamin D may play a role in preventing monophasic immune-mediated central nervous system attacks from developing into recurrent disease. Objective: To investigate the association between low serum vitamin D levels and recurrent spinal cord disease. Design, Setting, and Patients: We performed a retrospective analysis at Johns Hopkins Transverse Myelitis Center, Baltimore, Maryland, evaluating 25- hydroxyvitamin D levels in 77 patients with monophasic and recurrent inflammatory diseases of the spinal cord. Main Outcome Measure: Levels of 25-hydroxyvitamin D. Results: Vitamin D levels are significantly lower in patients who developed recurrent spinal cord disease, adjusting for season, age, sex, and race. Conclusions: This study provides a basis for a prospective trial of measuring 25-hydroxyvitaminDlevels in these patient populations and assessing the influence of vitamin D supplementation on the frequency of relapses in those with recurrent inflammatory spinal cord disease.
AB - Background: Low 25-hydroxyvitaminDlevels have been associated with a higher risk of developing multiple sclerosis and increased relapse rates in patients with multiple sclerosis. As a sterol hormone involved in multiple immunologic pathways, vitamin D may play a role in preventing monophasic immune-mediated central nervous system attacks from developing into recurrent disease. Objective: To investigate the association between low serum vitamin D levels and recurrent spinal cord disease. Design, Setting, and Patients: We performed a retrospective analysis at Johns Hopkins Transverse Myelitis Center, Baltimore, Maryland, evaluating 25- hydroxyvitamin D levels in 77 patients with monophasic and recurrent inflammatory diseases of the spinal cord. Main Outcome Measure: Levels of 25-hydroxyvitamin D. Results: Vitamin D levels are significantly lower in patients who developed recurrent spinal cord disease, adjusting for season, age, sex, and race. Conclusions: This study provides a basis for a prospective trial of measuring 25-hydroxyvitaminDlevels in these patient populations and assessing the influence of vitamin D supplementation on the frequency of relapses in those with recurrent inflammatory spinal cord disease.
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U2 - 10.1001/archneurol.2011.1974
DO - 10.1001/archneurol.2011.1974
M3 - Article
C2 - 22083799
AN - SCOPUS:84858587646
SN - 0003-9942
VL - 69
SP - 352
EP - 356
JO - Archives of neurology
JF - Archives of neurology
IS - 3
ER -