Low temperature organocopper-mediated two-component cross coupling/cycloisomerization approach toward N-fused heterocycles

Dmitri Chernyak, Surendra Babu Gadamsetty, Vladimir Gevorgyan

Research output: Contribution to journalArticle

76 Scopus citations

Abstract

(Chemical Equation Presented) Organocopper reagents smoothly react with heterocyclic propargyl mesylates at low temperature to produce N-fused heterocycles. The copper reagent plays a "double duty" in this novel cascade transformation, which proceeds via an SN2′ substitution followed by a subsequent cycloisomerization step.

Original languageEnglish (US)
Pages (from-to)2307-2310
Number of pages4
JournalOrganic Letters
Volume10
Issue number11
DOIs
StatePublished - Jun 5 2008
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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