Low-voltage aEEG as predictor of intracranial hemorrhage in preterm infants

Lina F. Chalak, Natalie C. Sikes, Melanie J. Mason, Jeffrey R. Kaiser

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

The objectives of this prospective cohort study were to identify amplitude-integrated electroencephalography (aEEG) background patterns predictive of severe intracranial hemorrhage. Thirty ventilated preterm newborns weighing <1,000 g were assessed by an aEEG cerebral function monitor and ultrasound measurement of cerebral blood flow velocity at time of surfactant administration and tracheal suctioning simultaneously during first 48 hours of life. Birth weight was 624 ± 200 g (mean ± S.D.) and gestational age was 25 ± 2 weeks. Background electrical activity was predominantly discontinuous in 72% of infants. A sharp increase in electrical activity/burst density was observed during surfactant administration and tracheal suctioning in most infants, with a 33.5% increase in mean cerebral blood flow velocity. Burst suppression with low voltage was identified in 57% infants with severe intracranial hemorrhage, whereas no infant without hemorrhage exhibited this pattern (P = 0.014). We conclude that aEEG low-voltage burst suppression might have useful clinical applications with 100% positive predictive value for severe intracranial hemorrhage.

Original languageEnglish (US)
Pages (from-to)364-369
Number of pages6
JournalPediatric Neurology
Volume44
Issue number5
DOIs
StatePublished - May 2011

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Intracranial Hemorrhages
Premature Infants
Electroencephalography
Cerebrovascular Circulation
Blood Flow Velocity
Surface-Active Agents
Birth Weight
Gestational Age
Cohort Studies
Newborn Infant
Prospective Studies
Hemorrhage

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health
  • Developmental Neuroscience
  • Neurology

Cite this

Low-voltage aEEG as predictor of intracranial hemorrhage in preterm infants. / Chalak, Lina F.; Sikes, Natalie C.; Mason, Melanie J.; Kaiser, Jeffrey R.

In: Pediatric Neurology, Vol. 44, No. 5, 05.2011, p. 364-369.

Research output: Contribution to journalArticle

Chalak, Lina F. ; Sikes, Natalie C. ; Mason, Melanie J. ; Kaiser, Jeffrey R. / Low-voltage aEEG as predictor of intracranial hemorrhage in preterm infants. In: Pediatric Neurology. 2011 ; Vol. 44, No. 5. pp. 364-369.
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