Lower Limits of Detection Using Magnetic Resonance Imaging for Solid Components in Cystic Renal Neoplasms

Gregory S. Adey, Ivan Pedrosa, Neil M. Rofsky, Martin G. Sanda, William C. DeWolf

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Objectives: We determined the positive predictive value (PPV) for malignancy in complex renal cysts with focal nodular enhancement seen on magnetic resonance imaging (MRI). Methods: A surgical database was reviewed to identify all patients having both a preoperative 3 dimensional (3D) renal MRI and a radical or partial nephrectomy from January 2000 through April 2004 at our hospital. A group of 21 patients were identified with focal nodular enhancement within cystic renal masses. Pathologic correlation was made in each case. Results: We performed 286 nephrectomies during the study period. Of these patients, 159 (56%) had a preoperative MRI studies. There were 21 of 159 (13%) patients with complex cystic lesions that displayed focal nodular enhancement, 14 of which (67%) measured 10 mm or larger in size. Twenty (95%) of the 21 lesions were renal cell carcinoma. The single, benign lesion was a cystic nephroma. Fuhrman grade 1 or grade 2 cancers were found in the majority of patients (80%), and there were no grade 4 cancers. Fifteen patients had a preoperative computerized tomography (CT) scan as well and nodular enhancement was suspected in only 4 patients (27%). MRI findings upgraded these lesions in 11 patients (73%). Conclusions: The demonstration of solid enhancing nodular components with high-resolution 3D MRI provides excellent positive predictive value for diagnosing neoplastic cystic renal lesions, including a large percentage 10 mm or larger in size. Our experience suggests a 95% likelihood that cystic renal lesions with focal nodular enhancement are malignant. We recommend that such lesions be considered malignant.

Original languageEnglish (US)
Pages (from-to)47-51
Number of pages5
JournalUrology
Volume71
Issue number1
DOIs
StatePublished - Jan 2008

Fingerprint

Kidney Neoplasms
Limit of Detection
Magnetic Resonance Imaging
Kidney
Nephrectomy
Neoplasms
Renal Cell Carcinoma
Cysts
Tomography
Databases

ASJC Scopus subject areas

  • Urology

Cite this

Lower Limits of Detection Using Magnetic Resonance Imaging for Solid Components in Cystic Renal Neoplasms. / Adey, Gregory S.; Pedrosa, Ivan; Rofsky, Neil M.; Sanda, Martin G.; DeWolf, William C.

In: Urology, Vol. 71, No. 1, 01.2008, p. 47-51.

Research output: Contribution to journalArticle

Adey, Gregory S. ; Pedrosa, Ivan ; Rofsky, Neil M. ; Sanda, Martin G. ; DeWolf, William C. / Lower Limits of Detection Using Magnetic Resonance Imaging for Solid Components in Cystic Renal Neoplasms. In: Urology. 2008 ; Vol. 71, No. 1. pp. 47-51.
@article{265e1c66db6b4906a69a356262d332e2,
title = "Lower Limits of Detection Using Magnetic Resonance Imaging for Solid Components in Cystic Renal Neoplasms",
abstract = "Objectives: We determined the positive predictive value (PPV) for malignancy in complex renal cysts with focal nodular enhancement seen on magnetic resonance imaging (MRI). Methods: A surgical database was reviewed to identify all patients having both a preoperative 3 dimensional (3D) renal MRI and a radical or partial nephrectomy from January 2000 through April 2004 at our hospital. A group of 21 patients were identified with focal nodular enhancement within cystic renal masses. Pathologic correlation was made in each case. Results: We performed 286 nephrectomies during the study period. Of these patients, 159 (56{\%}) had a preoperative MRI studies. There were 21 of 159 (13{\%}) patients with complex cystic lesions that displayed focal nodular enhancement, 14 of which (67{\%}) measured 10 mm or larger in size. Twenty (95{\%}) of the 21 lesions were renal cell carcinoma. The single, benign lesion was a cystic nephroma. Fuhrman grade 1 or grade 2 cancers were found in the majority of patients (80{\%}), and there were no grade 4 cancers. Fifteen patients had a preoperative computerized tomography (CT) scan as well and nodular enhancement was suspected in only 4 patients (27{\%}). MRI findings upgraded these lesions in 11 patients (73{\%}). Conclusions: The demonstration of solid enhancing nodular components with high-resolution 3D MRI provides excellent positive predictive value for diagnosing neoplastic cystic renal lesions, including a large percentage 10 mm or larger in size. Our experience suggests a 95{\%} likelihood that cystic renal lesions with focal nodular enhancement are malignant. We recommend that such lesions be considered malignant.",
author = "Adey, {Gregory S.} and Ivan Pedrosa and Rofsky, {Neil M.} and Sanda, {Martin G.} and DeWolf, {William C.}",
year = "2008",
month = "1",
doi = "10.1016/j.urology.2007.09.016",
language = "English (US)",
volume = "71",
pages = "47--51",
journal = "Urology",
issn = "0090-4295",
publisher = "Elsevier Inc.",
number = "1",

}

TY - JOUR

T1 - Lower Limits of Detection Using Magnetic Resonance Imaging for Solid Components in Cystic Renal Neoplasms

AU - Adey, Gregory S.

AU - Pedrosa, Ivan

AU - Rofsky, Neil M.

AU - Sanda, Martin G.

AU - DeWolf, William C.

PY - 2008/1

Y1 - 2008/1

N2 - Objectives: We determined the positive predictive value (PPV) for malignancy in complex renal cysts with focal nodular enhancement seen on magnetic resonance imaging (MRI). Methods: A surgical database was reviewed to identify all patients having both a preoperative 3 dimensional (3D) renal MRI and a radical or partial nephrectomy from January 2000 through April 2004 at our hospital. A group of 21 patients were identified with focal nodular enhancement within cystic renal masses. Pathologic correlation was made in each case. Results: We performed 286 nephrectomies during the study period. Of these patients, 159 (56%) had a preoperative MRI studies. There were 21 of 159 (13%) patients with complex cystic lesions that displayed focal nodular enhancement, 14 of which (67%) measured 10 mm or larger in size. Twenty (95%) of the 21 lesions were renal cell carcinoma. The single, benign lesion was a cystic nephroma. Fuhrman grade 1 or grade 2 cancers were found in the majority of patients (80%), and there were no grade 4 cancers. Fifteen patients had a preoperative computerized tomography (CT) scan as well and nodular enhancement was suspected in only 4 patients (27%). MRI findings upgraded these lesions in 11 patients (73%). Conclusions: The demonstration of solid enhancing nodular components with high-resolution 3D MRI provides excellent positive predictive value for diagnosing neoplastic cystic renal lesions, including a large percentage 10 mm or larger in size. Our experience suggests a 95% likelihood that cystic renal lesions with focal nodular enhancement are malignant. We recommend that such lesions be considered malignant.

AB - Objectives: We determined the positive predictive value (PPV) for malignancy in complex renal cysts with focal nodular enhancement seen on magnetic resonance imaging (MRI). Methods: A surgical database was reviewed to identify all patients having both a preoperative 3 dimensional (3D) renal MRI and a radical or partial nephrectomy from January 2000 through April 2004 at our hospital. A group of 21 patients were identified with focal nodular enhancement within cystic renal masses. Pathologic correlation was made in each case. Results: We performed 286 nephrectomies during the study period. Of these patients, 159 (56%) had a preoperative MRI studies. There were 21 of 159 (13%) patients with complex cystic lesions that displayed focal nodular enhancement, 14 of which (67%) measured 10 mm or larger in size. Twenty (95%) of the 21 lesions were renal cell carcinoma. The single, benign lesion was a cystic nephroma. Fuhrman grade 1 or grade 2 cancers were found in the majority of patients (80%), and there were no grade 4 cancers. Fifteen patients had a preoperative computerized tomography (CT) scan as well and nodular enhancement was suspected in only 4 patients (27%). MRI findings upgraded these lesions in 11 patients (73%). Conclusions: The demonstration of solid enhancing nodular components with high-resolution 3D MRI provides excellent positive predictive value for diagnosing neoplastic cystic renal lesions, including a large percentage 10 mm or larger in size. Our experience suggests a 95% likelihood that cystic renal lesions with focal nodular enhancement are malignant. We recommend that such lesions be considered malignant.

UR - http://www.scopus.com/inward/record.url?scp=38649091341&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=38649091341&partnerID=8YFLogxK

U2 - 10.1016/j.urology.2007.09.016

DO - 10.1016/j.urology.2007.09.016

M3 - Article

C2 - 18242363

AN - SCOPUS:38649091341

VL - 71

SP - 47

EP - 51

JO - Urology

JF - Urology

SN - 0090-4295

IS - 1

ER -