LRP

A bright beacon at the blood-brain barrier

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Ever more unexpected roles for the LDL receptor gene family in a variety of cellular signaling pathways continue to emerge. Three recent studies now add another function to this collection (see the related article beginning on page 1533). By interacting with active tissue-type plasminogen activator, LDL receptor-related protein appears to control permeability of the blood-brain barrier, vascular tone, and the expression of MMPs. All of these parameters impact upon postischemic infarct size following stroke. These novel findings are discussed in the context of known mechanisms of signaling by the LDL receptor family.

Original languageEnglish (US)
Pages (from-to)1483-1485
Number of pages3
JournalJournal of Clinical Investigation
Volume112
Issue number10
DOIs
StatePublished - Nov 2003

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LDL Receptors
Blood-Brain Barrier
Low Density Lipoprotein Receptor-Related Protein-1
Tissue Plasminogen Activator
Matrix Metalloproteinases
Blood Vessels
Permeability
Stroke
Genes

ASJC Scopus subject areas

  • Medicine(all)

Cite this

LRP : A bright beacon at the blood-brain barrier. / Herz, Joachim.

In: Journal of Clinical Investigation, Vol. 112, No. 10, 11.2003, p. 1483-1485.

Research output: Contribution to journalArticle

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