Luminal Na+/H+ exchange in the proximal tubule

I. Alexandru Bobulescu, Orson W. Moe

Research output: Contribution to journalArticle

78 Citations (Scopus)

Abstract

The proximal tubule is critical for whole-organism volume and acid-base homeostasis by reabsorbing filtered water, NaCl, bicarbonate, and citrate, as well as by excreting acid in the form of hydrogen and ammonium ions and producing new bicarbonate in the process. Filtered organic solutes such as amino acids, oligopeptides, and proteins are also retrieved by the proximal tubule. Luminal membrane Na+/H+ exchangers either directly mediate or indirectly contribute to each of these processes. Na+/H + exchangers are a family of secondary active transporters with diverse tissue and subcellular distributions. Two isoforms, NHE3 and NHE8, are expressed at the luminal membrane of the proximal tubule. NHE3 is the prevalent isoform in adults, is the most extensively studied, and is tightly regulated by a large number of agonists and physiological conditions acting via partially defined molecular mechanisms. Comparatively little is known about NHE8, which is highly expressed at the lumen of the neonatal proximal tubule and is mostly intracellular in adults. This article discusses the physiology of proximal Na+/H+ exchange, the multiple mechanisms of NHE3 regulation, and the reciprocal relationship between NHE3 and NHE8 at the lumen of the proximal tubule.

Original languageEnglish (US)
Pages (from-to)5-21
Number of pages17
JournalPflugers Archiv European Journal of Physiology
Volume458
Issue number1
DOIs
StatePublished - May 2009

Fingerprint

Sodium-Hydrogen Antiporter
Bicarbonates
Protein Isoforms
Membranes
Oligopeptides
Acids
Physiology
Tissue Distribution
Ammonium Compounds
Citric Acid
Protons
Hydrogen
Homeostasis
Ions
Tissue
Amino Acids
Water
Proteins

Keywords

  • Acid-based balance
  • Bicarbonate transport
  • Chloride transport
  • pH regulation
  • Sodium transport
  • Sodium-hydrogen exchange
  • Sodium-proton exchange
  • Volume regulation

ASJC Scopus subject areas

  • Physiology
  • Clinical Biochemistry
  • Physiology (medical)

Cite this

Luminal Na+/H+ exchange in the proximal tubule. / Bobulescu, I. Alexandru; Moe, Orson W.

In: Pflugers Archiv European Journal of Physiology, Vol. 458, No. 1, 05.2009, p. 5-21.

Research output: Contribution to journalArticle

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