Lung Cancer Explorer (LCE): An open web portal to explore gene expression and clinical associations in lung cancer

Ling Cai; Shin Yi Lin; Yunyun Zhou; Lin Yang; Bo Ci; Qinbo Zhou; Danni Luo; Bo Yao; Hao Tang; Jeffrey Allen; Kenneth Huffman; Adi F Gazdar; John Heymach; Ignacio Wistuba; Guanghua Xiao; John Minna; Yang Xie

doi:10.1101/271056

Lung Cancer Explorer (LCE): An open web portal to explore gene expression and clinical associations in lung cancer

Ling Cai, Shin Yi Lin, Yunyun Zhou, Lin Yang, Bo Ci, Qinbo Zhou, Danni Luo, Bo Yao, Hao Tang, Jeffrey Allen, Kenneth Huffman, Adi F Gazdar, John Heymach, Ignacio Wistuba, Guanghua Xiao, John Minna, Yang Xie

Research output: Contribution to journal › Article › peer-review

Abstract

We constructed a lung cancer-specific database housing expression data and clinical data from over 6,700 patients in 56 studies. Expression data from 23 “whole-genome” based platforms were carefully processed and quality controlled, whereas clinical data were standardized and rigorously curated. Empowered by this lung cancer database, we created an open access web resource – the Lung Cancer Explorer (LCE), which enables researchers and clinicians to explore these data and perform analyses. Users can perform meta-analyses on LCE to gain a quick overview of the results on tumor vs normal differential gene expression and expression-survival association. Individual dataset-based survival analysis, comparative analysis, and correlation analysis are also provided with flexible options to allow for customized analyses from the user.

Original language	English (US)
Journal	Unknown Journal
DOIs	https://doi.org/10.1101/271056
State	Published - Feb 24 2018

Keywords

clinical information
database
genomics
lung cancer
web application

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)
Agricultural and Biological Sciences(all)
Immunology and Microbiology(all)
Neuroscience(all)
Pharmacology, Toxicology and Pharmaceutics(all)

Access to Document

10.1101/271056

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Lung Cancer Explorer (LCE) : An open web portal to explore gene expression and clinical associations in lung cancer. / Cai, Ling; Lin, Shin Yi; Zhou, Yunyun; Yang, Lin; Ci, Bo; Zhou, Qinbo; Luo, Danni; Yao, Bo; Tang, Hao; Allen, Jeffrey; Huffman, Kenneth; Gazdar, Adi F; Heymach, John; Wistuba, Ignacio; Xiao, Guanghua ; Minna, John ; Xie, Yang.

In: Unknown Journal, 24.02.2018.

Research output: Contribution to journal › Article › peer-review

Cai, Ling ; Lin, Shin Yi ; Zhou, Yunyun ; Yang, Lin ; Ci, Bo ; Zhou, Qinbo ; Luo, Danni ; Yao, Bo ; Tang, Hao ; Allen, Jeffrey ; Huffman, Kenneth ; Gazdar, Adi F ; Heymach, John ; Wistuba, Ignacio ; Xiao, Guanghua ; Minna, John ; Xie, Yang. / Lung Cancer Explorer (LCE) : An open web portal to explore gene expression and clinical associations in lung cancer. In: Unknown Journal. 2018.

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abstract = "We constructed a lung cancer-specific database housing expression data and clinical data from over 6,700 patients in 56 studies. Expression data from 23 “whole-genome” based platforms were carefully processed and quality controlled, whereas clinical data were standardized and rigorously curated. Empowered by this lung cancer database, we created an open access web resource – the Lung Cancer Explorer (LCE), which enables researchers and clinicians to explore these data and perform analyses. Users can perform meta-analyses on LCE to gain a quick overview of the results on tumor vs normal differential gene expression and expression-survival association. Individual dataset-based survival analysis, comparative analysis, and correlation analysis are also provided with flexible options to allow for customized analyses from the user.",

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