Lung cancer signatures in plasma based on proteome profiling of mouse tumor models

Ayumu Taguchi, Katerina Politi, Sharon J. Pitteri, William W. Lockwood, Vitor M. Faça, Karen Kelly-Spratt, Chee Hong Wong, Qing Zhang, Alice Chin, Kwon Sik Park, Gary Goodman, Adi F. Gazdar, Julien Sage, Daniela M. Dinulescu, Raju Kucherlapati, Ronald A. DePinho, Christopher J. Kemp, Harold E. Varmus, Samir M. Hanash

Research output: Contribution to journalArticle

124 Scopus citations

Abstract

We investigated the potential of in-depth quantitative proteomics to reveal plasma protein signatures that reflect lung tumor biology. We compared plasma protein profiles of four mouse models of lung cancer with profiles of models of pancreatic, ovarian, colon, prostate, and breast cancer and two models of inflammation. A protein signature for Titf1/Nkx2-1, a known lineage-survival oncogene in lung cancer, was found in plasmas of mouse models of lung adenocarcinoma. An EGFR signature was found in plasma of an EGFR mutant model, and a distinct plasma signature related to neuroendocrine development was uncovered in the small-cell lung cancer model. We demonstrate relevance to human lung cancer of the protein signatures identified on the basis of mouse models.

Original languageEnglish (US)
Pages (from-to)289-299
Number of pages11
JournalCancer Cell
Volume20
Issue number3
DOIs
StatePublished - Sep 1 2011

ASJC Scopus subject areas

  • Oncology
  • Cell Biology
  • Cancer Research

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    Taguchi, A., Politi, K., Pitteri, S. J., Lockwood, W. W., Faça, V. M., Kelly-Spratt, K., Wong, C. H., Zhang, Q., Chin, A., Park, K. S., Goodman, G., Gazdar, A. F., Sage, J., Dinulescu, D. M., Kucherlapati, R., DePinho, R. A., Kemp, C. J., Varmus, H. E., & Hanash, S. M. (2011). Lung cancer signatures in plasma based on proteome profiling of mouse tumor models. Cancer Cell, 20(3), 289-299. https://doi.org/10.1016/j.ccr.2011.08.007