TY - JOUR
T1 - Lupus genes at the interface of tolerance and autoimmunity
AU - Calixto, Sergio M.
AU - Mohan, Chandra
N1 - Copyright:
Copyright 2009 Elsevier B.V., All rights reserved.
PY - 2007/7
Y1 - 2007/7
N2 - Systemic lupus erythematosus (SLE) is a complex and heterogeneous autoimmune disease of unclear etiology. However, it is widely accepted that the pathogenesis of SLE has a strong genetic component. Over the past 30 years, studies in mice and humans have uncovered many genes that are thought to be implicated in SLE development. Despite its heterogeneity, SLE is characterized primarily by high titers of autoantibodies to nuclear and cytoplasmic antigens. Over the years, this feature has led investigators to conclude that SLE develops, in part, as a consequence of a generalized loss of immune tolerance. This article reviews the genetics of SLE in the context of a breach of immune tolerance.
AB - Systemic lupus erythematosus (SLE) is a complex and heterogeneous autoimmune disease of unclear etiology. However, it is widely accepted that the pathogenesis of SLE has a strong genetic component. Over the past 30 years, studies in mice and humans have uncovered many genes that are thought to be implicated in SLE development. Despite its heterogeneity, SLE is characterized primarily by high titers of autoantibodies to nuclear and cytoplasmic antigens. Over the years, this feature has led investigators to conclude that SLE develops, in part, as a consequence of a generalized loss of immune tolerance. This article reviews the genetics of SLE in the context of a breach of immune tolerance.
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U2 - 10.1586/1744666X.3.4.603
DO - 10.1586/1744666X.3.4.603
M3 - Review article
C2 - 20477164
AN - SCOPUS:34447634903
SN - 1744-666X
VL - 3
SP - 603
EP - 611
JO - Expert review of clinical immunology
JF - Expert review of clinical immunology
IS - 4
ER -