Lupus: Key pathogenic mechanisms and contributing factors

Chandra Mohan, Syamal K. Datta

Research output: Contribution to journalReview article

103 Scopus citations

Abstract

The past 30 years of research on murine and human systemic lupus erythematosus has served to identify an array of immunological aberrations-some shared, some unique, some primary, others secondary-that may underlie this disease. In integrating these findings, it appears that at least four distinct pathogenic events characterize lupus: (1) Anti-DNA Abs and immune complexes induce renal damage; (2) B-cells produce pathogenic anti-DNA antibodies; (3) Th cells drive lupus B-cells; and (4) Increased concentrations and abnormal presentation of nucleosomes. The purpose of this review is to examine the roles of these four events in the pathogenesis of lupus and to identify the different factors that can precipitate these pathogenic events.

Original languageEnglish (US)
Pages (from-to)209-220
Number of pages12
JournalClinical Immunology and Immunopathology
Volume77
Issue number3
DOIs
StatePublished - Dec 1995

ASJC Scopus subject areas

  • Immunology and Allergy
  • Pathology and Forensic Medicine
  • Immunology

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