Luteinizing hormone-releasing hormone and thyrotropin-releasing hormone in the hypothalamus of women: Effects of age and reproductive status

C. R. Parker, J. C. Porter

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In the study of the effects of age and reproductive status on LHRH and TRH content in the hypothalamus of women, we found that the amount of LHRH (58 ± 5.5 ng; mean ± SE) in the hypothalamus of young women (16-29 yr) was significantly greater (P < 0.001) than that (28 ± 3.0 ng) in postmenopausal women (50-78 yr). The hypothalamic content of LHRH (18 ± 2.4 ng) of bilaterally ovariectomized women (39-47 yr) was significantly less (P < 0.001) than that (60 ± 12.6 ng) in younger ovulatory women (30-39 yr) or that (56 ± 13.5 ng) in ovulatory women of comparable age (40-49 yr). In contrast, the hypothalamic content of TRH (121.4 ± 32.8 ng) in postmenopausal women were similar to that (122.3 ± 12.5 ng) in young women. Although aging in women is associated with a significant reduction in the amount of LHRH in the hypothalamus, such a reduction appears to be a consequence of ovarian failure and not of aging per se.

Original languageEnglish (US)
Pages (from-to)488-491
Number of pages4
JournalJournal of Clinical Endocrinology and Metabolism
Issue number3
Publication statusPublished - 1984


ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

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