In the study of the effects of age and reproductive status on LHRH and TRH content in the hypothalamus of women, we found that the amount of LHRH (58 ± 5.5 ng; mean ± SE) in the hypothalamus of young women (16–29 yr) was significantly greater (P <0.0001) than that (28 ± 3.0 ng) in postmenopausal women (50–78 yr). The hypothalamic content of LHRH (18 ± 2.4 ng) of bilaterally ovariectomized women (39–47 yr) was significantly less (P < 0.001) than that (60 ± 12.6 ng) in younger ovulatory women (30–39 yr) or that (56 ± 13.5ng) in ovulatory women of comparable age (40–49 yr). In contrast, the hypothalamic content of TRH (121.4 ± 32.8 ng) in young women. Although aging in women is associated with a significant reduction in the amount of LHRH in the hypothalamus, such a reduction appears to be a consequence of ovarian failure and not of aging per se.
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
- Clinical Biochemistry
- Biochemistry, medical