LuXuRies of lipid homeostasis: the unity of nuclear hormone receptors, transcription regulation, and cholesterol sensing.

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

Cholesterol homeostasis is maintained by a regulatory network that controls both the acquisition and elimination of cholesterol. Recent studies have elucidated a mechanism by which cholesterol metabolism is transcriptionally regulated by several classes of orphan nuclear receptors. In particular, the liver X receptors, LXRalpha and LXRbeta, appear to serve as key sensors of intracellular sterol levels by regulating the expression of genes that control cholesterol absorption, storage, transport, and elimination. LXRs are also involved in fatty acid metabolism by their ability to increase the expression of sterol regulatory element-binding protein 1c (SREBP-1c). These findings define LXRs as potential therapeutic targets for the treatment of lipid disorders.

Original languageEnglish (US)
Pages (from-to)78-87
Number of pages10
JournalMol Interv
Volume2
Issue number2
StatePublished - Apr 2002

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Transcription
Cytoplasmic and Nuclear Receptors
Homeostasis
Cholesterol
Lipids
Metabolism
Orphan Nuclear Receptors
Sterol Regulatory Element Binding Protein 1
Sterols
Liver
Fatty Acids
Genes
Gene Expression
Sensors
Therapeutics

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacy

Cite this

LuXuRies of lipid homeostasis : the unity of nuclear hormone receptors, transcription regulation, and cholesterol sensing. / Zhang, Yuan; Mangelsdorf, David J.

In: Mol Interv, Vol. 2, No. 2, 04.2002, p. 78-87.

Research output: Contribution to journalArticle

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