Lymphangiogenesis and hemangiogenesis: Potential targets for therapy

Marlys H. Witte, Michael T. Dellinger, Donald M. McDonald, S. David Nathanson, Francesco M. Boccardo, Corradino C C Campisi, Jonathan P. Sleeman, Jeffrey E. Gershenwald

Research output: Contribution to journalArticle

24 Scopus citations


This review updates historical background from century-old observations on embryonic lymphatic system development through current understanding of the molecular basis of lymphvasculogenesis/lymphangiogenesis ("molecular lymphology"), highlighting similarities and differences with analogous blood vasculature processes. Topics covered include molecular mechanisms in lymphatic development, structural adaptations of the lymphatic vasculature to particulate and cellular transport and trafficking, lymphogenous route of clinical cancer spread, preservation of delineated lymphatic pathways during cancer operations, and anti-lymphangiogenesis in cancer therapy.

Original languageEnglish (US)
Pages (from-to)489-500
Number of pages12
JournalJournal of Surgical Oncology
Issue number6
Publication statusPublished - May 1 2011



  • angiogenesis
  • anti-lymphangiogenesis
  • lymphatic development
  • lymphogenous cancer spread

ASJC Scopus subject areas

  • Surgery
  • Oncology

Cite this

Witte, M. H., Dellinger, M. T., McDonald, D. M., Nathanson, S. D., Boccardo, F. M., Campisi, C. C. C., ... Gershenwald, J. E. (2011). Lymphangiogenesis and hemangiogenesis: Potential targets for therapy. Journal of Surgical Oncology, 103(6), 489-500.