Lymphokine-induced IgM secretion by clones of neoplastic B cells

Kathryn Brooks, Dorothy Yuan, Jonathan W. Uhr, Peter H. Krammer, Ellen S. Vitetta

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Abstract

The induction of antibody secretion by B cells requires T-cell-derived factors1-5. Such factors have been described1,2,6-12 but the precise relationship among these various factors is not clear, and it has been difficult to demonstrate that these factors act directly on the B cell and do not exert their effect via T cells or macrophages. In this report we describe the direct induction of IgM synthesis and secretion in cloned lines of long-term tissue culture adapted neoplastic B cells (BCL1) by T-cell super-natants from phorbol-12-myristate 13-acetate (PMA)-induced EL-4 cells or concanavalin A (Con A)-induced 7.1.1a cells5,9. We have termed this activity BCDFμ (B-cell differentiation factor for IgM). The supernatants containing BCDFμ induce activated and neoplastic B cells to secrete IgM 5 and the factor responsible is distinct from BCGF13, interleukin-2 (IL-2)5, the classical T-cell replacing factor (TRF) described by Schimpl and Wecker5, and immune interferem (IFNγ)5.

Original languageEnglish (US)
Pages (from-to)825-826
Number of pages2
JournalNature
Volume302
Issue number5911
DOIs
StatePublished - Dec 1 1983

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    Brooks, K., Yuan, D., Uhr, J. W., Krammer, P. H., & Vitetta, E. S. (1983). Lymphokine-induced IgM secretion by clones of neoplastic B cells. Nature, 302(5911), 825-826. https://doi.org/10.1038/302825a0