Lymphokines in rheumatoid synovitis

P. Stastny, M. Rosenthal, M. Andreis

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

In antigen induced experimental arthritis of rabbits, a macrophage migration inhibitory factor was released from the inflamed synovial tissues. A migration inhibitory factor, blastogenic factor, and B cell stimulating factor were also found in human rheumatoid synovial fluids and culture supernatants of rheumatoid tissue explants. Joint fluids from patients with inflammatory conditions other than rheumatoid arthritis sometimes also displayed these activities. Osteoarthritis fluids were usually inactive. At present, little is known of the origin or role in vivo of the lymphokine like activities observed in the joints of rheumatoid patients. In related experiments, injection of lymphokine rich antigen free lymphocyte supernatants into normal rabbit knee joints produced a synovitis characterized by lining layer hyperplasia and infiltration of the sublining layer by macrophages. The lymphocytic and plasmacytic components seen in active antigen induced synovitis were absent. It seems likely that some of the changes observed in active chronic synovitis are mediated by soluble factors of the lymphokine variety.

Original languageEnglish (US)
Pages (from-to)117-131
Number of pages15
JournalAnnals of the New York Academy of Sciences
VolumeVol. 256
StatePublished - 1975

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Synovitis
Lymphokines
Antigens
Fluids
Joints
Tissue
Macrophage Migration-Inhibitory Factors
Rabbits
Experimental Arthritis
Lymphocytes
Macrophages
Synovial Fluid
Knee Joint
Linings
Infiltration
Osteoarthritis
Hyperplasia
Rheumatoid Arthritis
B-Lymphocytes
Cells

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Stastny, P., Rosenthal, M., & Andreis, M. (1975). Lymphokines in rheumatoid synovitis. Annals of the New York Academy of Sciences, Vol. 256, 117-131.

Lymphokines in rheumatoid synovitis. / Stastny, P.; Rosenthal, M.; Andreis, M.

In: Annals of the New York Academy of Sciences, Vol. Vol. 256, 1975, p. 117-131.

Research output: Contribution to journalArticle

Stastny, P, Rosenthal, M & Andreis, M 1975, 'Lymphokines in rheumatoid synovitis', Annals of the New York Academy of Sciences, vol. Vol. 256, pp. 117-131.
Stastny P, Rosenthal M, Andreis M. Lymphokines in rheumatoid synovitis. Annals of the New York Academy of Sciences. 1975;Vol. 256:117-131.
Stastny, P. ; Rosenthal, M. ; Andreis, M. / Lymphokines in rheumatoid synovitis. In: Annals of the New York Academy of Sciences. 1975 ; Vol. Vol. 256. pp. 117-131.
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