Lymphotoxin organizes contributions to host defense and metabolic illness from innate lymphoid cells

Vaibhav Upadhyay, Yang Xin Fu

Research output: Contribution to journalShort surveypeer-review

9 Scopus citations

Abstract

The lymphotoxin (LT)-pathway is a unique constituent branch of the Tumor Necrosis Superfamily (TNFSF). Use of LT is a critical mechanism by which fetal innate lymphoid cells regulate lymphoid organogenesis. Within recent years, adult innate lymphoid cells have been discovered to utilize this same pathway to regulate IL-22 and IL-23 production for host defense. Notably, genetic studies have linked polymorphisms in the genes encoding LTα to several phenotypes contributing to metabolic syndrome. The role of the LT-pathway may lay the foundation for a bridge between host immune response, microbiota, and metabolic syndrome. The contribution of the LT-pathway to innate lymphoid cell function and metabolic syndrome will be visited in this review.

Original languageEnglish (US)
Pages (from-to)227-233
Number of pages7
JournalCytokine and Growth Factor Reviews
Volume25
Issue number2
DOIs
StatePublished - Apr 2014

Keywords

  • Host defense
  • Innate lymphoid cells
  • Lymphotoxin
  • Metabolic syndrome
  • Microbiota

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Immunology and Allergy
  • Immunology
  • Biochemistry, Genetics and Molecular Biology(all)

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