Abstract
The lymphotoxin (LT)-pathway is a unique constituent branch of the Tumor Necrosis Superfamily (TNFSF). Use of LT is a critical mechanism by which fetal innate lymphoid cells regulate lymphoid organogenesis. Within recent years, adult innate lymphoid cells have been discovered to utilize this same pathway to regulate IL-22 and IL-23 production for host defense. Notably, genetic studies have linked polymorphisms in the genes encoding LTα to several phenotypes contributing to metabolic syndrome. The role of the LT-pathway may lay the foundation for a bridge between host immune response, microbiota, and metabolic syndrome. The contribution of the LT-pathway to innate lymphoid cell function and metabolic syndrome will be visited in this review.
Original language | English (US) |
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Pages (from-to) | 227-233 |
Number of pages | 7 |
Journal | Cytokine and Growth Factor Reviews |
Volume | 25 |
Issue number | 2 |
DOIs | |
State | Published - Apr 2014 |
Keywords
- Host defense
- Innate lymphoid cells
- Lymphotoxin
- Metabolic syndrome
- Microbiota
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
- Immunology and Allergy
- Immunology
- General Biochemistry, Genetics and Molecular Biology