Lymphotoxin signalling in immune homeostasis and the control of microorganisms

Vaibhav Upadhyay, Yang Xin Fu

Research output: Contribution to journalReview article

45 Citations (Scopus)

Abstract

Lymphotoxin (LT) is a member of the tumour necrosis factor (TNF) superfamily that was originally thought to be functionally redundant to TNF, but these proteins were later found to have independent roles in driving lymphoid organogenesis. More recently, LT-mediated signalling has been shown to actively contribute to effector immune responses. LT regulates dendritic cell and CD4+ T cell homeostasis in the steady state and determines the functions of these cells during pathogenic challenges. The LT receptor pathway is essential for controlling pathogens and even contributes to the regulation of the intestinal microbiota, with recent data suggesting that LT-induced changes in the microbiota promote metabolic disease. In this Review, we discuss these newly defined roles for LT, with a particular focus on how the LT receptor pathway regulates innate and adaptive immune responses to microorganisms.

Original languageEnglish (US)
Pages (from-to)270-279
Number of pages10
JournalNature Reviews Immunology
Volume13
Issue number4
DOIs
StatePublished - Apr 1 2013

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Lymphotoxin-alpha
Homeostasis
Tumor Necrosis Factor-alpha
Organogenesis
Microbiota
Metabolic Diseases
Adaptive Immunity
Innate Immunity
Dendritic Cells
T-Lymphocytes

ASJC Scopus subject areas

  • Immunology

Cite this

Lymphotoxin signalling in immune homeostasis and the control of microorganisms. / Upadhyay, Vaibhav; Fu, Yang Xin.

In: Nature Reviews Immunology, Vol. 13, No. 4, 01.04.2013, p. 270-279.

Research output: Contribution to journalReview article

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