Lymphotoxin signalling in tertiary lymphoid structures and immunotherapy

Haidong Tang, Mingzhao Zhu, Jian Qiao, Yang Xin Fu

Research output: Contribution to journalReview article

4 Citations (Scopus)

Abstract

Tertiary lymphoid structures (TLS) often develop at sites of persistent inflammation, including cancers and autoimmune diseases. In most cases, the presence of TLS correlates with active immune responses. Because of their proximity to pathological loci, TLS are an intriguing target for the manipulation of immune responses. For several years, it has become clear that lymphotoxin (LT) signalling plays critical roles in lymphoid tissue organogenesis and maintenance. In the current review, we will discuss the role of LT signalling in the development of TLS. With a focus on cancers and autoimmune diseases, we will highlight the correlations between TLS and disease progression. We will also discuss the current efforts and potential directions for manipulating TLS for immunotherapies.

Original languageEnglish (US)
Pages (from-to)809-818
Number of pages10
JournalCellular and Molecular Immunology
Volume14
Issue number10
DOIs
StatePublished - Oct 1 2017

Fingerprint

Lymphotoxin-alpha
Immunotherapy
Autoimmune Diseases
Active Immunity
Organogenesis
Lymphoid Tissue
Disease Progression
Tertiary Lymphoid Structures
Neoplasms
Maintenance
Inflammation

Keywords

  • autoimmune disease
  • cancer
  • immunotherapy
  • lymphotoxin signalling
  • tertiary lymphoid structure

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

Cite this

Lymphotoxin signalling in tertiary lymphoid structures and immunotherapy. / Tang, Haidong; Zhu, Mingzhao; Qiao, Jian; Fu, Yang Xin.

In: Cellular and Molecular Immunology, Vol. 14, No. 10, 01.10.2017, p. 809-818.

Research output: Contribution to journalReview article

@article{3a16a28b54ec499590f26760e0851af7,
title = "Lymphotoxin signalling in tertiary lymphoid structures and immunotherapy",
abstract = "Tertiary lymphoid structures (TLS) often develop at sites of persistent inflammation, including cancers and autoimmune diseases. In most cases, the presence of TLS correlates with active immune responses. Because of their proximity to pathological loci, TLS are an intriguing target for the manipulation of immune responses. For several years, it has become clear that lymphotoxin (LT) signalling plays critical roles in lymphoid tissue organogenesis and maintenance. In the current review, we will discuss the role of LT signalling in the development of TLS. With a focus on cancers and autoimmune diseases, we will highlight the correlations between TLS and disease progression. We will also discuss the current efforts and potential directions for manipulating TLS for immunotherapies.",
keywords = "autoimmune disease, cancer, immunotherapy, lymphotoxin signalling, tertiary lymphoid structure",
author = "Haidong Tang and Mingzhao Zhu and Jian Qiao and Fu, {Yang Xin}",
year = "2017",
month = "10",
day = "1",
doi = "10.1038/cmi.2017.13",
language = "English (US)",
volume = "14",
pages = "809--818",
journal = "Cellular and Molecular Immunology",
issn = "1672-7681",
publisher = "Nature Publishing Group",
number = "10",

}

TY - JOUR

T1 - Lymphotoxin signalling in tertiary lymphoid structures and immunotherapy

AU - Tang, Haidong

AU - Zhu, Mingzhao

AU - Qiao, Jian

AU - Fu, Yang Xin

PY - 2017/10/1

Y1 - 2017/10/1

N2 - Tertiary lymphoid structures (TLS) often develop at sites of persistent inflammation, including cancers and autoimmune diseases. In most cases, the presence of TLS correlates with active immune responses. Because of their proximity to pathological loci, TLS are an intriguing target for the manipulation of immune responses. For several years, it has become clear that lymphotoxin (LT) signalling plays critical roles in lymphoid tissue organogenesis and maintenance. In the current review, we will discuss the role of LT signalling in the development of TLS. With a focus on cancers and autoimmune diseases, we will highlight the correlations between TLS and disease progression. We will also discuss the current efforts and potential directions for manipulating TLS for immunotherapies.

AB - Tertiary lymphoid structures (TLS) often develop at sites of persistent inflammation, including cancers and autoimmune diseases. In most cases, the presence of TLS correlates with active immune responses. Because of their proximity to pathological loci, TLS are an intriguing target for the manipulation of immune responses. For several years, it has become clear that lymphotoxin (LT) signalling plays critical roles in lymphoid tissue organogenesis and maintenance. In the current review, we will discuss the role of LT signalling in the development of TLS. With a focus on cancers and autoimmune diseases, we will highlight the correlations between TLS and disease progression. We will also discuss the current efforts and potential directions for manipulating TLS for immunotherapies.

KW - autoimmune disease

KW - cancer

KW - immunotherapy

KW - lymphotoxin signalling

KW - tertiary lymphoid structure

UR - http://www.scopus.com/inward/record.url?scp=85031285320&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85031285320&partnerID=8YFLogxK

U2 - 10.1038/cmi.2017.13

DO - 10.1038/cmi.2017.13

M3 - Review article

VL - 14

SP - 809

EP - 818

JO - Cellular and Molecular Immunology

JF - Cellular and Molecular Immunology

SN - 1672-7681

IS - 10

ER -