Lymphovascular invasion is associated with oncologic outcomes following radical cystectomy for squamous cell carcinoma of the urinary bladder

Kyle Spradling, Yair Lotan, Ahmed Shokeir, Hassan Abol-Enein, Ahmed Mosbah, Jacob B. Morgan, Mohamed Ghoneim, Ramy F. Youssef

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Objective: To evaluate the association of lymphovascular invasion (LVI) with oncologic outcomes of squamous cell carcinoma (SCC) of the urinary bladder following radical cystectomy (RC). Patients and methods: We performed a retrospective analysis of 1,280 patients who underwent RC for invasive bladder cancer between 1997 and 2003 in Mansoura, Egypt. Only patients with pure urothelial carcinoma of the bladder (UCB) or SCC pathology were included. Using multivariate Cox regression analyses and Kaplan-Meier analyses, prognostic significance of LVI in disease-free survival and cancer-specific survival was evaluated for patients with UCB and SCC. Results: Our cohort included 519 (59%) patients with UCB and 360 (41%) with SCC. Median patient age and follow-up were 55 years (20-87) and 64 months (0-128), respectively. Median number of lymph nodes (LN) retrieved was 19 (4-70). LVI was present in 288 (32.8%) patients (241 [46.4%] UCB vs. 47 [13.1%] SCC; P

Original languageEnglish (US)
JournalUrologic Oncology: Seminars and Original Investigations
DOIs
StateAccepted/In press - Jan 24 2016

Keywords

  • Bladder cancer
  • Lymphovascular invasion
  • Squamous cell carcinoma
  • Urothelial carcinoma

ASJC Scopus subject areas

  • Oncology
  • Urology

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