Abstract
Objective: To evaluate the association of lymphovascular invasion (LVI) with oncologic outcomes of squamous cell carcinoma (SCC) of the urinary bladder following radical cystectomy (RC). Patients and methods: We performed a retrospective analysis of 1,280 patients who underwent RC for invasive bladder cancer between 1997 and 2003 in Mansoura, Egypt. Only patients with pure urothelial carcinoma of the bladder (UCB) or SCC pathology were included. Using multivariate Cox regression analyses and Kaplan-Meier analyses, prognostic significance of LVI in disease-free survival and cancer-specific survival was evaluated for patients with UCB and SCC. Results: Our cohort included 519 (59%) patients with UCB and 360 (41%) with SCC. Median patient age and follow-up were 55 years (20-87) and 64 months (0-128), respectively. Median number of lymph nodes (LN) retrieved was 19 (4-70). LVI was present in 288 (32.8%) patients (241 [46.4%] UCB vs. 47 [13.1%] SCC; P
| Original language | English (US) |
|---|---|
| Journal | Urologic Oncology: Seminars and Original Investigations |
| DOIs | |
| State | Accepted/In press - Jan 24 2016 |
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Keywords
- Bladder cancer
- Lymphovascular invasion
- Squamous cell carcinoma
- Urothelial carcinoma
ASJC Scopus subject areas
- Oncology
- Urology
Cite this
Lymphovascular invasion is associated with oncologic outcomes following radical cystectomy for squamous cell carcinoma of the urinary bladder. / Spradling, Kyle; Lotan, Yair; Shokeir, Ahmed; Abol-Enein, Hassan; Mosbah, Ahmed; Morgan, Jacob B.; Ghoneim, Mohamed; Youssef, Ramy F.
In: Urologic Oncology: Seminars and Original Investigations, 24.01.2016.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Lymphovascular invasion is associated with oncologic outcomes following radical cystectomy for squamous cell carcinoma of the urinary bladder
AU - Spradling, Kyle
AU - Lotan, Yair
AU - Shokeir, Ahmed
AU - Abol-Enein, Hassan
AU - Mosbah, Ahmed
AU - Morgan, Jacob B.
AU - Ghoneim, Mohamed
AU - Youssef, Ramy F.
PY - 2016/1/24
Y1 - 2016/1/24
N2 - Objective: To evaluate the association of lymphovascular invasion (LVI) with oncologic outcomes of squamous cell carcinoma (SCC) of the urinary bladder following radical cystectomy (RC). Patients and methods: We performed a retrospective analysis of 1,280 patients who underwent RC for invasive bladder cancer between 1997 and 2003 in Mansoura, Egypt. Only patients with pure urothelial carcinoma of the bladder (UCB) or SCC pathology were included. Using multivariate Cox regression analyses and Kaplan-Meier analyses, prognostic significance of LVI in disease-free survival and cancer-specific survival was evaluated for patients with UCB and SCC. Results: Our cohort included 519 (59%) patients with UCB and 360 (41%) with SCC. Median patient age and follow-up were 55 years (20-87) and 64 months (0-128), respectively. Median number of lymph nodes (LN) retrieved was 19 (4-70). LVI was present in 288 (32.8%) patients (241 [46.4%] UCB vs. 47 [13.1%] SCC; P
AB - Objective: To evaluate the association of lymphovascular invasion (LVI) with oncologic outcomes of squamous cell carcinoma (SCC) of the urinary bladder following radical cystectomy (RC). Patients and methods: We performed a retrospective analysis of 1,280 patients who underwent RC for invasive bladder cancer between 1997 and 2003 in Mansoura, Egypt. Only patients with pure urothelial carcinoma of the bladder (UCB) or SCC pathology were included. Using multivariate Cox regression analyses and Kaplan-Meier analyses, prognostic significance of LVI in disease-free survival and cancer-specific survival was evaluated for patients with UCB and SCC. Results: Our cohort included 519 (59%) patients with UCB and 360 (41%) with SCC. Median patient age and follow-up were 55 years (20-87) and 64 months (0-128), respectively. Median number of lymph nodes (LN) retrieved was 19 (4-70). LVI was present in 288 (32.8%) patients (241 [46.4%] UCB vs. 47 [13.1%] SCC; P
KW - Bladder cancer
KW - Lymphovascular invasion
KW - Squamous cell carcinoma
KW - Urothelial carcinoma
UR - http://www.scopus.com/inward/record.url?scp=84964882809&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84964882809&partnerID=8YFLogxK
U2 - 10.1016/j.urolonc.2016.03.023
DO - 10.1016/j.urolonc.2016.03.023
M3 - Article
C2 - 27157247
AN - SCOPUS:84964882809
JO - Urologic Oncology: Seminars and Original Investigations
JF - Urologic Oncology: Seminars and Original Investigations
SN - 1078-1439
ER -