Lymphovascular invasion is associated with oncologic outcomes following radical cystectomy for squamous cell carcinoma of the urinary bladder

Kyle Spradling, Yair Lotan, Ahmed Shokeir, Hassan Abol-Enein, Ahmed Mosbah, Jacob B. Morgan, Mohamed Ghoneim, Ramy F. Youssef

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Objective: To evaluate the association of lymphovascular invasion (LVI) with oncologic outcomes of squamous cell carcinoma (SCC) of the urinary bladder following radical cystectomy (RC). Patients and methods: We performed a retrospective analysis of 1,280 patients who underwent RC for invasive bladder cancer between 1997 and 2003 in Mansoura, Egypt. Only patients with pure urothelial carcinoma of the bladder (UCB) or SCC pathology were included. Using multivariate Cox regression analyses and Kaplan-Meier analyses, prognostic significance of LVI in disease-free survival and cancer-specific survival was evaluated for patients with UCB and SCC. Results: Our cohort included 519 (59%) patients with UCB and 360 (41%) with SCC. Median patient age and follow-up were 55 years (20-87) and 64 months (0-128), respectively. Median number of lymph nodes (LN) retrieved was 19 (4-70). LVI was present in 288 (32.8%) patients (241 [46.4%] UCB vs. 47 [13.1%] SCC; P

Original languageEnglish (US)
JournalUrologic Oncology: Seminars and Original Investigations
DOIs
StateAccepted/In press - Jan 24 2016

Fingerprint

Cystectomy
Squamous Cell Carcinoma
Urinary Bladder
Carcinoma
Egypt
Kaplan-Meier Estimate
Urinary Bladder Neoplasms
Disease-Free Survival
Lymph Nodes
Regression Analysis
Pathology
Survival
Neoplasms

Keywords

  • Bladder cancer
  • Lymphovascular invasion
  • Squamous cell carcinoma
  • Urothelial carcinoma

ASJC Scopus subject areas

  • Oncology
  • Urology

Cite this

Lymphovascular invasion is associated with oncologic outcomes following radical cystectomy for squamous cell carcinoma of the urinary bladder. / Spradling, Kyle; Lotan, Yair; Shokeir, Ahmed; Abol-Enein, Hassan; Mosbah, Ahmed; Morgan, Jacob B.; Ghoneim, Mohamed; Youssef, Ramy F.

In: Urologic Oncology: Seminars and Original Investigations, 24.01.2016.

Research output: Contribution to journalArticle

Spradling, Kyle ; Lotan, Yair ; Shokeir, Ahmed ; Abol-Enein, Hassan ; Mosbah, Ahmed ; Morgan, Jacob B. ; Ghoneim, Mohamed ; Youssef, Ramy F. / Lymphovascular invasion is associated with oncologic outcomes following radical cystectomy for squamous cell carcinoma of the urinary bladder. In: Urologic Oncology: Seminars and Original Investigations. 2016.
@article{fa5315d3a5c348d1b38e57bc6cf19cc7,
title = "Lymphovascular invasion is associated with oncologic outcomes following radical cystectomy for squamous cell carcinoma of the urinary bladder",
abstract = "Objective: To evaluate the association of lymphovascular invasion (LVI) with oncologic outcomes of squamous cell carcinoma (SCC) of the urinary bladder following radical cystectomy (RC). Patients and methods: We performed a retrospective analysis of 1,280 patients who underwent RC for invasive bladder cancer between 1997 and 2003 in Mansoura, Egypt. Only patients with pure urothelial carcinoma of the bladder (UCB) or SCC pathology were included. Using multivariate Cox regression analyses and Kaplan-Meier analyses, prognostic significance of LVI in disease-free survival and cancer-specific survival was evaluated for patients with UCB and SCC. Results: Our cohort included 519 (59{\%}) patients with UCB and 360 (41{\%}) with SCC. Median patient age and follow-up were 55 years (20-87) and 64 months (0-128), respectively. Median number of lymph nodes (LN) retrieved was 19 (4-70). LVI was present in 288 (32.8{\%}) patients (241 [46.4{\%}] UCB vs. 47 [13.1{\%}] SCC; P",
keywords = "Bladder cancer, Lymphovascular invasion, Squamous cell carcinoma, Urothelial carcinoma",
author = "Kyle Spradling and Yair Lotan and Ahmed Shokeir and Hassan Abol-Enein and Ahmed Mosbah and Morgan, {Jacob B.} and Mohamed Ghoneim and Youssef, {Ramy F.}",
year = "2016",
month = "1",
day = "24",
doi = "10.1016/j.urolonc.2016.03.023",
language = "English (US)",
journal = "Urologic Oncology: Seminars and Original Investigations",
issn = "1078-1439",
publisher = "Elsevier Inc.",

}

TY - JOUR

T1 - Lymphovascular invasion is associated with oncologic outcomes following radical cystectomy for squamous cell carcinoma of the urinary bladder

AU - Spradling, Kyle

AU - Lotan, Yair

AU - Shokeir, Ahmed

AU - Abol-Enein, Hassan

AU - Mosbah, Ahmed

AU - Morgan, Jacob B.

AU - Ghoneim, Mohamed

AU - Youssef, Ramy F.

PY - 2016/1/24

Y1 - 2016/1/24

N2 - Objective: To evaluate the association of lymphovascular invasion (LVI) with oncologic outcomes of squamous cell carcinoma (SCC) of the urinary bladder following radical cystectomy (RC). Patients and methods: We performed a retrospective analysis of 1,280 patients who underwent RC for invasive bladder cancer between 1997 and 2003 in Mansoura, Egypt. Only patients with pure urothelial carcinoma of the bladder (UCB) or SCC pathology were included. Using multivariate Cox regression analyses and Kaplan-Meier analyses, prognostic significance of LVI in disease-free survival and cancer-specific survival was evaluated for patients with UCB and SCC. Results: Our cohort included 519 (59%) patients with UCB and 360 (41%) with SCC. Median patient age and follow-up were 55 years (20-87) and 64 months (0-128), respectively. Median number of lymph nodes (LN) retrieved was 19 (4-70). LVI was present in 288 (32.8%) patients (241 [46.4%] UCB vs. 47 [13.1%] SCC; P

AB - Objective: To evaluate the association of lymphovascular invasion (LVI) with oncologic outcomes of squamous cell carcinoma (SCC) of the urinary bladder following radical cystectomy (RC). Patients and methods: We performed a retrospective analysis of 1,280 patients who underwent RC for invasive bladder cancer between 1997 and 2003 in Mansoura, Egypt. Only patients with pure urothelial carcinoma of the bladder (UCB) or SCC pathology were included. Using multivariate Cox regression analyses and Kaplan-Meier analyses, prognostic significance of LVI in disease-free survival and cancer-specific survival was evaluated for patients with UCB and SCC. Results: Our cohort included 519 (59%) patients with UCB and 360 (41%) with SCC. Median patient age and follow-up were 55 years (20-87) and 64 months (0-128), respectively. Median number of lymph nodes (LN) retrieved was 19 (4-70). LVI was present in 288 (32.8%) patients (241 [46.4%] UCB vs. 47 [13.1%] SCC; P

KW - Bladder cancer

KW - Lymphovascular invasion

KW - Squamous cell carcinoma

KW - Urothelial carcinoma

UR - http://www.scopus.com/inward/record.url?scp=84964882809&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84964882809&partnerID=8YFLogxK

U2 - 10.1016/j.urolonc.2016.03.023

DO - 10.1016/j.urolonc.2016.03.023

M3 - Article

C2 - 27157247

AN - SCOPUS:84964882809

JO - Urologic Oncology: Seminars and Original Investigations

JF - Urologic Oncology: Seminars and Original Investigations

SN - 1078-1439

ER -