Lysine vasopressin in alzheimer disease

R. Durso; P. Fedio; P. Brouwers; C. Cox; A. J. Martin; S. A. Ruggieri; C. A. Tamminga; T. N. Chase

doi:10.1212/wnl.32.6.674

Lysine vasopressin in alzheimer disease

R. Durso, P. Fedio, P. Brouwers, C. Cox, A. J. Martin, S. A. Ruggieri, C. A. Tamminga, T. N. Chase

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

Abstract

The effect of lysine vasopressin on memory and cog nitive deficits in Alzheimer disease was investigated. In a double-blind study, seven patients were given 16 units of lysine vasopressin per day for 10 days and were compared with seven different patients receiving placebo. No significant difference in performance between the vasopressin and placebo-treated groups was found in tests designed to evaluate learning, memory, and perception. However, significantly greater im provement in reaction time was seen in the vasopressin-treated group, although this effect was delayed and may have been contributed to by factors other than drug activity.

Original language	English (US)
Pages (from-to)	674-677
Number of pages	4
Journal	Neurology
Volume	32
Issue number	6
DOIs	https://doi.org/10.1212/wnl.32.6.674
State	Published - Jun 1982

ASJC Scopus subject areas

Clinical Neurology

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AU - Durso, R.

AU - Fedio, P.

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AU - Ruggieri, S. A.

AU - Tamminga, C. A.

AU - Chase, T. N.

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AB - The effect of lysine vasopressin on memory and cog nitive deficits in Alzheimer disease was investigated. In a double-blind study, seven patients were given 16 units of lysine vasopressin per day for 10 days and were compared with seven different patients receiving placebo. No significant difference in performance between the vasopressin and placebo-treated groups was found in tests designed to evaluate learning, memory, and perception. However, significantly greater im provement in reaction time was seen in the vasopressin-treated group, although this effect was delayed and may have been contributed to by factors other than drug activity.

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Lysine vasopressin in alzheimer disease

Abstract

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