Lysosomal enzymes in the development and regression of myocardial hypertrophy induced by systemic hypertension

Kern Wildenthal, Edward A. Mueller

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Left ventricular hypertrophy was induced in unilaterally-nephrectomized rats by excess dietary salt intake, with or without injections of deoxycorticosterone (DOCA). No changes occurred in the cardiac activities or distribution of several lysosomal enzymes (cathepsin D, acid phosphatase, β-acetylglucosaminidase). Similarly, regression of hypertrophy after return to normal salt intake and cessation of DOCA was unaccompanied by any changes in the enzymes. These results suggest that significant changes in lysosomal function are not an important feature of the development or regression of cardiac hypertrophy induced by systemic hypertension.

Original languageEnglish (US)
Pages (from-to)121-130
Number of pages10
JournalJournal of Molecular and Cellular Cardiology
Volume9
Issue number2
DOIs
StatePublished - Feb 1977

Keywords

  • Acid phosphatase
  • Cathepsin D
  • Deoxycorticosterone
  • Salt diet
  • β-Acetylglucosaminidase

ASJC Scopus subject areas

  • Molecular Biology
  • Cardiology and Cardiovascular Medicine

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