A computerized PubMed search of MEDLINE 1966-May 2005 was performed. The terms Meniere disease and gentamicin were exploded, and the resulting articles were combined. The terms intratympanic and transtympanic were entered as text words as the search term intratympanic OR transtympanic, and the results were combined with the Ménière disease/gentamicin articles. The resulting 136 articles were limited to the English language, leading to the selection of 115 articles that were reviewed in detail. These articles were reviewed to identify those that met the following inclusion criteria: 1) distinct patient populations defined as those adults with definite Ménière disease, as defined by the 1985  or 1995  guidelines of the Committee on Hearing and Equilibrium of the American Academy of Otolaryngology-Head and Neck Surgery (AAO-HNS), who had failed medical management, 2) intervention with unilateral intratympanic gentamicin therapy, and 3) outcome measures consisting of quantitative or semiquantitative evaluation of vestibular complaints.
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