Macrophage chitinase 1 stratifies chronic obstructive lung disease

Eugene Agapov, John T. Battaile, Rose Tidwell, Ramsey Hachem, G. Alexander Patterson, Richard A. Pierce, Jeffrey J. Atkinson, Michael J. Holtzman

Research output: Contribution to journalArticle

39 Scopus citations

Abstract

Diagnosis and therapy of chronic inflammatory lung disease is limited by the need for individualized biomarkers that provide insight into pathogenesis. Herein we show that mouse models of chronic obstructive lung disease exhibit an increase in lung chitinase production but cannot predict which chitinase family member may be equivalently increased in humans with corresponding lung disease. Moreover, we demonstrate that lung macrophage production of chitinase 1 is selectively increased in a subset of subjects with severe chronic obstructive pulmonary disease, and this increase is reflected in plasma levels. The findings provide a means to noninvasively track alternatively activated macrophages in chronic lung disease and thereby better differentiate molecular phenotypes in heterogeneous patient populations.

Original languageEnglish (US)
Pages (from-to)379-384
Number of pages6
JournalAmerican journal of respiratory cell and molecular biology
Volume41
Issue number4
DOIs
StatePublished - Oct 1 2009

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ASJC Scopus subject areas

  • Molecular Biology
  • Pulmonary and Respiratory Medicine
  • Clinical Biochemistry
  • Cell Biology

Cite this

Agapov, E., Battaile, J. T., Tidwell, R., Hachem, R., Patterson, G. A., Pierce, R. A., Atkinson, J. J., & Holtzman, M. J. (2009). Macrophage chitinase 1 stratifies chronic obstructive lung disease. American journal of respiratory cell and molecular biology, 41(4), 379-384. https://doi.org/10.1165/2009-0122R