Macrophage ontogeny: Implications for host defence, T-lymphocyte differentiation, and the acquisition of self-tolerance

C. Y. Lu, E. R. Unanue

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

It has become increasingly more apparent that Ia-bearing accessory cells are important in regulating the function of mature T lymphocytes as well as the maturation of immature T lymphocytes in the thymus. The experiments reviewed here have focused on the ontogeny of Ia-bearing macrophages in the peritoneal cavity, spleen, and thymus. In the former two sites, Ia-bearing macrophages appear late in ontogeny. This makes the neonate and fetus vulnerable to infection, but may also offer the immune system a critical mechanism for inducing self-tolerance. The delayed ontogenesis of Ia-bearing macrophages at these two sites is regulated by high concentrations of PGE2 as well as alpha-fetoprotein. On the other hand, Ia-bearing thymic macrophages are present early in ontogeny and may contribute to the expansion and maturation of appropriate T lymphocyte clones early in development.

Original languageEnglish (US)
Pages (from-to)253-269
Number of pages17
JournalClinics in Immunology and Allergy
Volume5
Issue number2
StatePublished - Jan 1 1985

ASJC Scopus subject areas

  • Immunology and Allergy

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