Macrophages in Renal Injury and Repair

Sarah Huen, Lloyd G. Cantley

Research output: Contribution to journalReview article

66 Scopus citations

Abstract

Acute kidney injury (AKI) is a growing global health concern, yet no treatment is currently available to prevent it or to promote kidney repair after injury. Animal models demonstrate that the macrophage is a major contributor to the inflammatory response to AKI. Emerging data from human biopsies also corroborate the presence of macrophages in AKI and their persistence in progressive chronic kidney disease. Macrophages are phagocytic innate immune cells that are important mediators of tissue homeostasis and host defense. In response to tissue injury, macrophages become activated based on specific signals from the damaged microenvironment. The activation and functional state of the macrophage depends on the stage of tissue injury and repair, reflecting a dynamic and diverse spectrum of macrophage phenotypes. In this review, we highlight our current understanding of the mechanisms by which macrophages contribute to injury and repair after AKI.

Original languageEnglish (US)
Pages (from-to)449-469
Number of pages21
JournalAnnual Review of Physiology
Volume79
DOIs
StatePublished - Feb 10 2017

Keywords

  • Acute kidney injury
  • Dendritic cells
  • Ischemia reperfusion
  • Macrophage activation
  • Monocytes
  • Renal fibrosis

ASJC Scopus subject areas

  • Physiology

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