Abstract
Multidrug-resistant strains of pathogens necessitate development of alternative means to prevent and treat bacterial infections. Bacterial adherence to host tissues is a universally required early step for establishing infections and, thus, targeting this process holds promise as an alternative approach to conventional antibiotics for treating bacterial infections. Because anti-adhesive compounds clear rather than kill bacteria, there is no selective pressure on the pathogen to develop resistance to this process, reducing the likelihood that a dominantly resistant population will develop. Although several compounds show promise, the wider use of anti-adhesion therapy will depend on the discovery of new anti-adhesion drug targets and on compounds with better affinity, stability, and bioavailability.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 286-290 |
| Number of pages | 5 |
| Journal | Microbe |
| Volume | 8 |
| Issue number | 7 |
| State | Published - Jul 2013 |
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ASJC Scopus subject areas
- Microbiology
Cite this
Made to stick : Anti-adhesion therapy for bacterial infections. / Krachler, Anne Marie; Orth, Kim.
In: Microbe, Vol. 8, No. 7, 07.2013, p. 286-290.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Made to stick
T2 - Anti-adhesion therapy for bacterial infections
AU - Krachler, Anne Marie
AU - Orth, Kim
PY - 2013/7
Y1 - 2013/7
N2 - Multidrug-resistant strains of pathogens necessitate development of alternative means to prevent and treat bacterial infections. Bacterial adherence to host tissues is a universally required early step for establishing infections and, thus, targeting this process holds promise as an alternative approach to conventional antibiotics for treating bacterial infections. Because anti-adhesive compounds clear rather than kill bacteria, there is no selective pressure on the pathogen to develop resistance to this process, reducing the likelihood that a dominantly resistant population will develop. Although several compounds show promise, the wider use of anti-adhesion therapy will depend on the discovery of new anti-adhesion drug targets and on compounds with better affinity, stability, and bioavailability.
AB - Multidrug-resistant strains of pathogens necessitate development of alternative means to prevent and treat bacterial infections. Bacterial adherence to host tissues is a universally required early step for establishing infections and, thus, targeting this process holds promise as an alternative approach to conventional antibiotics for treating bacterial infections. Because anti-adhesive compounds clear rather than kill bacteria, there is no selective pressure on the pathogen to develop resistance to this process, reducing the likelihood that a dominantly resistant population will develop. Although several compounds show promise, the wider use of anti-adhesion therapy will depend on the discovery of new anti-adhesion drug targets and on compounds with better affinity, stability, and bioavailability.
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UR - http://www.scopus.com/inward/citedby.url?scp=84880096618&partnerID=8YFLogxK
M3 - Article
VL - 8
SP - 286
EP - 290
JO - ASM News
JF - ASM News
SN - 1558-7452
IS - 7
ER -