Abstract
Multidrug-resistant strains of pathogens necessitate development of alternative means to prevent and treat bacterial infections. Bacterial adherence to host tissues is a universally required early step for establishing infections and, thus, targeting this process holds promise as an alternative approach to conventional antibiotics for treating bacterial infections. Because anti-adhesive compounds clear rather than kill bacteria, there is no selective pressure on the pathogen to develop resistance to this process, reducing the likelihood that a dominantly resistant population will develop. Although several compounds show promise, the wider use of anti-adhesion therapy will depend on the discovery of new anti-adhesion drug targets and on compounds with better affinity, stability, and bioavailability.
Original language | English (US) |
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Pages (from-to) | 286-290 |
Number of pages | 5 |
Journal | Microbe |
Volume | 8 |
Issue number | 7 |
State | Published - Jul 1 2013 |
ASJC Scopus subject areas
- Microbiology