Made to stick: Anti-adhesion therapy for bacterial infections

Anne Marie Krachler, Kim Orth

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Multidrug-resistant strains of pathogens necessitate development of alternative means to prevent and treat bacterial infections. Bacterial adherence to host tissues is a universally required early step for establishing infections and, thus, targeting this process holds promise as an alternative approach to conventional antibiotics for treating bacterial infections. Because anti-adhesive compounds clear rather than kill bacteria, there is no selective pressure on the pathogen to develop resistance to this process, reducing the likelihood that a dominantly resistant population will develop. Although several compounds show promise, the wider use of anti-adhesion therapy will depend on the discovery of new anti-adhesion drug targets and on compounds with better affinity, stability, and bioavailability.

Original languageEnglish (US)
Pages (from-to)286-290
Number of pages5
JournalMicrobe
Volume8
Issue number7
StatePublished - Jul 1 2013

ASJC Scopus subject areas

  • Microbiology

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