TY - JOUR
T1 - Made to stick
T2 - Anti-adhesion therapy for bacterial infections
AU - Krachler, Anne Marie
AU - Orth, Kim
PY - 2013/7
Y1 - 2013/7
N2 - Multidrug-resistant strains of pathogens necessitate development of alternative means to prevent and treat bacterial infections. Bacterial adherence to host tissues is a universally required early step for establishing infections and, thus, targeting this process holds promise as an alternative approach to conventional antibiotics for treating bacterial infections. Because anti-adhesive compounds clear rather than kill bacteria, there is no selective pressure on the pathogen to develop resistance to this process, reducing the likelihood that a dominantly resistant population will develop. Although several compounds show promise, the wider use of anti-adhesion therapy will depend on the discovery of new anti-adhesion drug targets and on compounds with better affinity, stability, and bioavailability.
AB - Multidrug-resistant strains of pathogens necessitate development of alternative means to prevent and treat bacterial infections. Bacterial adherence to host tissues is a universally required early step for establishing infections and, thus, targeting this process holds promise as an alternative approach to conventional antibiotics for treating bacterial infections. Because anti-adhesive compounds clear rather than kill bacteria, there is no selective pressure on the pathogen to develop resistance to this process, reducing the likelihood that a dominantly resistant population will develop. Although several compounds show promise, the wider use of anti-adhesion therapy will depend on the discovery of new anti-adhesion drug targets and on compounds with better affinity, stability, and bioavailability.
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U2 - 10.1128/microbe.8.286.1
DO - 10.1128/microbe.8.286.1
M3 - Article
AN - SCOPUS:84880096618
SN - 1558-7452
VL - 8
SP - 286
EP - 290
JO - Microbe
JF - Microbe
IS - 7
ER -