Magnesium sulfate therapy affects attention and working memory in patients undergoing preterm labor

Nirali Ghia, Catherine Y. Spong, Victoria N. Starbuck, Anthony R. Scialli, Alessandro Ghidini

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

OBJECTIVE: Patients commonly consent to undergoing invasive procedures while receiving magnesium sulfate therapy. This study evaluated the effects of magnesium sulfate on attention, comprehension, and memory in patients undergoing preterm labor. STUDY DESIGN: Consenting patients were studied while receiving(study) and not receiving (control) intravenous magnesium sulfate tocolysis for preterm labor. Excluded were patients with possible preeclampsia, imminent delivery, sedative administration, or prior mental illness. Patient comprehension was assessed with the Boston Diagnostic Aphasia Examination. Level of attention and working memory were evaluated with the Paced Auditory Serial Addition Test. Verbal learning, short-term memory, and recognition were determined with the Hopkins Verbal Learning Test. Gross mental-neurologic deficits were evaluated with the Mini-Mental Status Examination. The tests were administered by the same examiner. Control testing was performed >24 hours after intravenous magnesium sulfate was discontinued. Magnesium levels were obtained at the time of testing. The primary outcome measure was the Paced Auditory Serial Addition Test score because of its ability to elicit subtle differences in attention capacity. Statistical analysis included the paired t test and the McNemar test. RESULTS: Fifteen patients completed the study. Paced Auditory Serial Addition Test scores were significantly higher (ie, more errors were made) during magnesium sulfate therapy than periods without therapy (14 ± 8 vs 7 ± 7; P < .05). Comprehension (Boston Diagnostic Aphasia Examination score) was not different between the groups (P = .7). There was no difference in short-term memory (Hopkins Verbal Learning Test) or gross mental-neurologic deficits between the 2 groups (all P > .1). CONCLUSIONS: Magnesium sulfate therapy appears to have an effect on attention and working memory but not on long-term memory or comprehension. The significant differences in Paced Auditory Serial Addition Test scores reveal deficits in information-processing ability in patients on a regimen of magnesium sulfate therapy.

Original languageEnglish (US)
Pages (from-to)940-944
Number of pages5
JournalAmerican journal of obstetrics and gynecology
Volume183
Issue number4
DOIs
StatePublished - Jan 1 2000
Externally publishedYes

Fingerprint

Magnesium Sulfate
Premature Obstetric Labor
Short-Term Memory
Verbal Learning
Aptitude
Therapeutics
Tocolysis
Long-Term Memory
Aphasia
Neurologic Manifestations
Pre-Eclampsia
Hypnotics and Sedatives
Automatic Data Processing
Magnesium
Outcome Assessment (Health Care)

Keywords

  • Attention
  • Comprehension
  • Informed consent
  • Magnesium sulfate
  • Preterm labor
  • Tocolysis

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Magnesium sulfate therapy affects attention and working memory in patients undergoing preterm labor. / Ghia, Nirali; Spong, Catherine Y.; Starbuck, Victoria N.; Scialli, Anthony R.; Ghidini, Alessandro.

In: American journal of obstetrics and gynecology, Vol. 183, No. 4, 01.01.2000, p. 940-944.

Research output: Contribution to journalArticle

Ghia, Nirali ; Spong, Catherine Y. ; Starbuck, Victoria N. ; Scialli, Anthony R. ; Ghidini, Alessandro. / Magnesium sulfate therapy affects attention and working memory in patients undergoing preterm labor. In: American journal of obstetrics and gynecology. 2000 ; Vol. 183, No. 4. pp. 940-944.
@article{12a25e4da313465f893c5f2b6b5b657b,
title = "Magnesium sulfate therapy affects attention and working memory in patients undergoing preterm labor",
abstract = "OBJECTIVE: Patients commonly consent to undergoing invasive procedures while receiving magnesium sulfate therapy. This study evaluated the effects of magnesium sulfate on attention, comprehension, and memory in patients undergoing preterm labor. STUDY DESIGN: Consenting patients were studied while receiving(study) and not receiving (control) intravenous magnesium sulfate tocolysis for preterm labor. Excluded were patients with possible preeclampsia, imminent delivery, sedative administration, or prior mental illness. Patient comprehension was assessed with the Boston Diagnostic Aphasia Examination. Level of attention and working memory were evaluated with the Paced Auditory Serial Addition Test. Verbal learning, short-term memory, and recognition were determined with the Hopkins Verbal Learning Test. Gross mental-neurologic deficits were evaluated with the Mini-Mental Status Examination. The tests were administered by the same examiner. Control testing was performed >24 hours after intravenous magnesium sulfate was discontinued. Magnesium levels were obtained at the time of testing. The primary outcome measure was the Paced Auditory Serial Addition Test score because of its ability to elicit subtle differences in attention capacity. Statistical analysis included the paired t test and the McNemar test. RESULTS: Fifteen patients completed the study. Paced Auditory Serial Addition Test scores were significantly higher (ie, more errors were made) during magnesium sulfate therapy than periods without therapy (14 ± 8 vs 7 ± 7; P < .05). Comprehension (Boston Diagnostic Aphasia Examination score) was not different between the groups (P = .7). There was no difference in short-term memory (Hopkins Verbal Learning Test) or gross mental-neurologic deficits between the 2 groups (all P > .1). CONCLUSIONS: Magnesium sulfate therapy appears to have an effect on attention and working memory but not on long-term memory or comprehension. The significant differences in Paced Auditory Serial Addition Test scores reveal deficits in information-processing ability in patients on a regimen of magnesium sulfate therapy.",
keywords = "Attention, Comprehension, Informed consent, Magnesium sulfate, Preterm labor, Tocolysis",
author = "Nirali Ghia and Spong, {Catherine Y.} and Starbuck, {Victoria N.} and Scialli, {Anthony R.} and Alessandro Ghidini",
year = "2000",
month = "1",
day = "1",
doi = "10.1067/mob.2000.109045",
language = "English (US)",
volume = "183",
pages = "940--944",
journal = "American Journal of Obstetrics and Gynecology",
issn = "0002-9378",
publisher = "Mosby Inc.",
number = "4",

}

TY - JOUR

T1 - Magnesium sulfate therapy affects attention and working memory in patients undergoing preterm labor

AU - Ghia, Nirali

AU - Spong, Catherine Y.

AU - Starbuck, Victoria N.

AU - Scialli, Anthony R.

AU - Ghidini, Alessandro

PY - 2000/1/1

Y1 - 2000/1/1

N2 - OBJECTIVE: Patients commonly consent to undergoing invasive procedures while receiving magnesium sulfate therapy. This study evaluated the effects of magnesium sulfate on attention, comprehension, and memory in patients undergoing preterm labor. STUDY DESIGN: Consenting patients were studied while receiving(study) and not receiving (control) intravenous magnesium sulfate tocolysis for preterm labor. Excluded were patients with possible preeclampsia, imminent delivery, sedative administration, or prior mental illness. Patient comprehension was assessed with the Boston Diagnostic Aphasia Examination. Level of attention and working memory were evaluated with the Paced Auditory Serial Addition Test. Verbal learning, short-term memory, and recognition were determined with the Hopkins Verbal Learning Test. Gross mental-neurologic deficits were evaluated with the Mini-Mental Status Examination. The tests were administered by the same examiner. Control testing was performed >24 hours after intravenous magnesium sulfate was discontinued. Magnesium levels were obtained at the time of testing. The primary outcome measure was the Paced Auditory Serial Addition Test score because of its ability to elicit subtle differences in attention capacity. Statistical analysis included the paired t test and the McNemar test. RESULTS: Fifteen patients completed the study. Paced Auditory Serial Addition Test scores were significantly higher (ie, more errors were made) during magnesium sulfate therapy than periods without therapy (14 ± 8 vs 7 ± 7; P < .05). Comprehension (Boston Diagnostic Aphasia Examination score) was not different between the groups (P = .7). There was no difference in short-term memory (Hopkins Verbal Learning Test) or gross mental-neurologic deficits between the 2 groups (all P > .1). CONCLUSIONS: Magnesium sulfate therapy appears to have an effect on attention and working memory but not on long-term memory or comprehension. The significant differences in Paced Auditory Serial Addition Test scores reveal deficits in information-processing ability in patients on a regimen of magnesium sulfate therapy.

AB - OBJECTIVE: Patients commonly consent to undergoing invasive procedures while receiving magnesium sulfate therapy. This study evaluated the effects of magnesium sulfate on attention, comprehension, and memory in patients undergoing preterm labor. STUDY DESIGN: Consenting patients were studied while receiving(study) and not receiving (control) intravenous magnesium sulfate tocolysis for preterm labor. Excluded were patients with possible preeclampsia, imminent delivery, sedative administration, or prior mental illness. Patient comprehension was assessed with the Boston Diagnostic Aphasia Examination. Level of attention and working memory were evaluated with the Paced Auditory Serial Addition Test. Verbal learning, short-term memory, and recognition were determined with the Hopkins Verbal Learning Test. Gross mental-neurologic deficits were evaluated with the Mini-Mental Status Examination. The tests were administered by the same examiner. Control testing was performed >24 hours after intravenous magnesium sulfate was discontinued. Magnesium levels were obtained at the time of testing. The primary outcome measure was the Paced Auditory Serial Addition Test score because of its ability to elicit subtle differences in attention capacity. Statistical analysis included the paired t test and the McNemar test. RESULTS: Fifteen patients completed the study. Paced Auditory Serial Addition Test scores were significantly higher (ie, more errors were made) during magnesium sulfate therapy than periods without therapy (14 ± 8 vs 7 ± 7; P < .05). Comprehension (Boston Diagnostic Aphasia Examination score) was not different between the groups (P = .7). There was no difference in short-term memory (Hopkins Verbal Learning Test) or gross mental-neurologic deficits between the 2 groups (all P > .1). CONCLUSIONS: Magnesium sulfate therapy appears to have an effect on attention and working memory but not on long-term memory or comprehension. The significant differences in Paced Auditory Serial Addition Test scores reveal deficits in information-processing ability in patients on a regimen of magnesium sulfate therapy.

KW - Attention

KW - Comprehension

KW - Informed consent

KW - Magnesium sulfate

KW - Preterm labor

KW - Tocolysis

UR - http://www.scopus.com/inward/record.url?scp=0033792224&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033792224&partnerID=8YFLogxK

U2 - 10.1067/mob.2000.109045

DO - 10.1067/mob.2000.109045

M3 - Article

C2 - 11035343

AN - SCOPUS:0033792224

VL - 183

SP - 940

EP - 944

JO - American Journal of Obstetrics and Gynecology

JF - American Journal of Obstetrics and Gynecology

SN - 0002-9378

IS - 4

ER -