Magnetic field correlation as a measure of iron-generated magnetic field inhomogeneities in the brain

Jens H. Jensen; Kamila Szulc; Caixia Hu; Anita Ramani; Hanzhang Lu; Liang Xuan; Maria F. Falangola; Ramesh Chandra; Edmond A. Knopp; John Schenck; Earl A. Zimmerman; Joseph A. Helpern

doi:10.1002/mrm.21823

Magnetic field correlation as a measure of iron-generated magnetic field inhomogeneities in the brain

Jens H. Jensen, Kamila Szulc, Caixia Hu, Anita Ramani, Hanzhang Lu, Liang Xuan, Maria F. Falangola, Ramesh Chandra, Edmond A. Knopp, John Schenck, Earl A. Zimmerman, Joseph A. Helpern

Advanced Imaging Research Center

Research output: Contribution to journal › Article › peer-review

40 Scopus citations

Abstract

The magnetic field correlation (MFC) at an applied field level of 3 Tesla was estimated by means of MRI in several brain regions for 21 healthy human adults and 1 subject with aceruloplasminemia. For healthy subjects, highly elevated MFC values compared with surrounding tissues were found within the basal ganglia. These are argued as being primarily the result of microscopic magnetic field inhomogeneities generated by non- heme brain iron. The MFC in the aceruloplasminemia subject was significantly higher than for healthy adults in the globus pallidus, thalamus and frontal white matter, consistent with the known increased brain iron concentration associated with this disease.

Original language	English (US)
Pages (from-to)	481-485
Number of pages	5
Journal	Magnetic resonance in medicine
Volume	61
Issue number	2
DOIs	https://doi.org/10.1002/mrm.21823
State	Published - Feb 2009

Keywords

Aceruloplasminemia
Brain
Iron
MRI
Magnetic field correlation
Magnetic field inhomogeneities

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

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10.1002/mrm.21823

Cite this

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abstract = "The magnetic field correlation (MFC) at an applied field level of 3 Tesla was estimated by means of MRI in several brain regions for 21 healthy human adults and 1 subject with aceruloplasminemia. For healthy subjects, highly elevated MFC values compared with surrounding tissues were found within the basal ganglia. These are argued as being primarily the result of microscopic magnetic field inhomogeneities generated by non- heme brain iron. The MFC in the aceruloplasminemia subject was significantly higher than for healthy adults in the globus pallidus, thalamus and frontal white matter, consistent with the known increased brain iron concentration associated with this disease.",

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AU - Jensen, Jens H.

AU - Szulc, Kamila

AU - Hu, Caixia

AU - Ramani, Anita

AU - Lu, Hanzhang

AU - Xuan, Liang

AU - Falangola, Maria F.

AU - Chandra, Ramesh

AU - Knopp, Edmond A.

AU - Schenck, John

AU - Zimmerman, Earl A.

AU - Helpern, Joseph A.

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AB - The magnetic field correlation (MFC) at an applied field level of 3 Tesla was estimated by means of MRI in several brain regions for 21 healthy human adults and 1 subject with aceruloplasminemia. For healthy subjects, highly elevated MFC values compared with surrounding tissues were found within the basal ganglia. These are argued as being primarily the result of microscopic magnetic field inhomogeneities generated by non- heme brain iron. The MFC in the aceruloplasminemia subject was significantly higher than for healthy adults in the globus pallidus, thalamus and frontal white matter, consistent with the known increased brain iron concentration associated with this disease.

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KW - Iron

KW - MRI

KW - Magnetic field correlation

KW - Magnetic field inhomogeneities

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Magnetic field correlation as a measure of iron-generated magnetic field inhomogeneities in the brain

Abstract

Keywords

ASJC Scopus subject areas

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