Magnetic resonance imaging and spectroscopy in offspring at risk for schizophrenia: Preliminary studies

Matcheri S. Keshavan, Debra M. Montrose, Joseph N. Pierri, Elizabeth L. Dick, David Rosenberg, Lalith Talagala, John A. Sweeney

Research output: Contribution to journalArticle

120 Scopus citations

Abstract

1. Studies of first-degree relatives of persons with schizophrenia provide an opportunity to characterize risk factors for the development of this illness. In this report the authors will provide preliminary data from an ongoing study of neurobiological alterations in the offspring of schizophrenia patients. 2. A series of offspring of schizophrenic patients (OS) were compared with age and sex matched healthy controls (HC) without psychiatric history in first degree relatives on psychiatric, volumetric Magnetic Resonance Imaging (MRI) of whole brain and proton Magnetic Resonance Spectroscopy (1H MRS) evaluations of the ventral prefrontal cortex. 3. Compared with HC group, high risk subjects had reduced left amygdala volume, enlarged third ventricular volume, and smaller overall brain volume. 4. 1H MRS studies showed a trend for decreased NAA/choline ratios in the anterior cingulate region in the OS group as compared to HC subjects. 5. Follow-up studies of these subjects are needed to confirm the predictive value of these measures for future emergence of schizophrenia in subjects at risk for this illness.

Original languageEnglish (US)
Pages (from-to)1285-1295
Number of pages11
JournalProgress in Neuro-Psychopharmacology and Biological Psychiatry
Volume21
Issue number8
DOIs
StatePublished - Nov 1 1997

Keywords

  • Amygdala
  • Hippocampus
  • N-acetyl aspartate
  • Offspring
  • Schizophrenia
  • Third ventricle

ASJC Scopus subject areas

  • Pharmacology
  • Biological Psychiatry

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