Magnetic resonance imaging of muscle injury and atrophy in glycolytic myopathies

J. L. Fleckenstein, Ronald M Peshock, S. F. Lewis, Ronald G Haller

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Exertional muscle pain, contractures, recurrent rhabdomyolysis, and pigmenturia are common in certain muscle glycotylic disorders. However, the frequency, distribution, and long-term significance of these findings are poorly understood. First we performed magnetic resonance imaging (MRI) of the extremities as a screening test for the detection of muscle abnormalities incurred in activities of daily living in four patients with myophosphorylase deficiency (MPD) and three with muscle phosphofructokinase deficiency (PFKD). MRI findings of abnormal muscles detected upon screening were next compared with changes observed in a prospective study of muscle contractures involving the forearms of four of the patients (two MPD, two PFKD). Screening revealed abnormalities of proximal thigh muscles in three of seven patients, in two of whom (one MPD, one PFKD) a recent history of exertional myalgia coincided with increases in T1 and T2 estimates of isolated thigh muscles. In the third patient (PFKD), focal atrophy of the adductor magnus was present bilaterally. In prospective studies, focal areas of prolonged T1 and T2 appeared in the flexor digitorum superficialis in all four cases and in the flexor digitorum profundus in two cases. Serial imaging suggested that the onset of MRI abnormalities begins within 24 hours of contracture and persists for at least several days and possibly for much longer, with complete recovery apparently the rule. These cases suggests a high prevelance of focal muscle abnormalities in patients with glycolytic myopathies and who the potential of MRI to detect them.

Original languageEnglish (US)
Pages (from-to)849-855
Number of pages7
JournalMuscle and Nerve
Volume12
Issue number10
StatePublished - 1989

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Muscular Atrophy
Muscular Diseases
Glycogen Storage Disease Type V
Magnetic Resonance Imaging
Phosphofructokinases
Muscles
Wounds and Injuries
Contracture
Myalgia
Thigh
Glycogen Storage Disease Type VII
Prospective Studies
Rhabdomyolysis
Activities of Daily Living
Forearm
Atrophy
Extremities

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Magnetic resonance imaging of muscle injury and atrophy in glycolytic myopathies. / Fleckenstein, J. L.; Peshock, Ronald M; Lewis, S. F.; Haller, Ronald G.

In: Muscle and Nerve, Vol. 12, No. 10, 1989, p. 849-855.

Research output: Contribution to journalArticle

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