Magnetic resonance imaging of the brain:blood partition coefficient for water: Application to spin-tagging measurement of perfusion

David A. Roberts, Rahim Rizi, Robert E. Lenkinski, John S. Leigh

Research output: Contribution to journalArticle

53 Scopus citations

Abstract

We describe the use of relative proton density imaging to obtain spatially resolved measurements of the brain:blood partition coefficient for water. Values of relative proton density and apparent-T1 were calculated by performing a multidimensional nonlinear least squares fit of progressive saturation image data. Correction for magnetic field inhomogeneity was included. The partition coefficient was calculated by dividing the relative proton density of brain by the relative proton density of blood water. Results obtained from healthy volunteers demonstrate significant spatial variation in the partition coefficient in brain. Direct measurement of this parameter eliminates a source of error in the calculation of regional perfusion using arterial spin-tagging techniques.

Original languageEnglish (US)
Pages (from-to)363-366
Number of pages4
JournalJournal of Magnetic Resonance Imaging
Volume6
Issue number2
DOIs
StatePublished - Jan 1 1996

Keywords

  • Functional imaging
  • MRI
  • Partition coefficient
  • Perfusion imaging
  • Spin-tagging

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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