Magnetic resonance imaging of the caudate nuclei in depression

Preliminary observations

K. Ranga Rama Krishnan, William M. McDonald, P. Rodrigo Escalona, P. Murali Doraiswamy, Chul Na, Mustafa M. Husain, Gary S. Figiel, Orest B. Boyko, Everett H. Ellinwood, Charles B. Nemeroff

Research output: Contribution to journalArticle

290 Citations (Scopus)

Abstract

A role of the caudate nucleus in depression has been suggested from relevant clinical conditions, such as patients with Huntington's disease or caudate infarcts, as well as animal studies. Correlations of caudate nucleus disease with depressive symptoms have been limited to autopsy studies and cases of gross pathological disorder, such as large infarcts. We used serial axial high-field magnetic resonance images and an unbiased stereological technique to estimate the volumes of the caudate nuclei in 50 patients who met DSM-III criteria for major depression (23 men, 48.3 ± 17 years old) in comparison with 50 age- and gender-matched normal controls free of major neurological and psychiatric disorders. Depressed patients had smaller caudate nucleus volumes (5.2±1.6 cm3) compared with controls (6.2±1.7 cm3). Right and left caudate nucleus volumes were smaller in depressed patients compared with controls. Age was negatively correlated with caudate nucleus volumes in depressed patients as well as in controls. Caudate nucleus volumes in depressed patients were inversely correlated with the bicaudate and bifrontal indices. These results may be the first demonstration of diminished caudate nucleus volumes in depression and suggest a role for the caudate nucleus in the pathogenesis of major depression.

Original languageEnglish (US)
Pages (from-to)553-557
Number of pages5
JournalArchives of General Psychiatry
Volume49
Issue number7
StatePublished - 1992

Fingerprint

Caudate Nucleus
Magnetic Resonance Imaging
Depression
Huntington Disease
Nervous System Diseases
Diagnostic and Statistical Manual of Mental Disorders
Psychiatry
Autopsy
Magnetic Resonance Spectroscopy

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Krishnan, K. R. R., McDonald, W. M., Escalona, P. R., Doraiswamy, P. M., Na, C., Husain, M. M., ... Nemeroff, C. B. (1992). Magnetic resonance imaging of the caudate nuclei in depression: Preliminary observations. Archives of General Psychiatry, 49(7), 553-557.

Magnetic resonance imaging of the caudate nuclei in depression : Preliminary observations. / Krishnan, K. Ranga Rama; McDonald, William M.; Escalona, P. Rodrigo; Doraiswamy, P. Murali; Na, Chul; Husain, Mustafa M.; Figiel, Gary S.; Boyko, Orest B.; Ellinwood, Everett H.; Nemeroff, Charles B.

In: Archives of General Psychiatry, Vol. 49, No. 7, 1992, p. 553-557.

Research output: Contribution to journalArticle

Krishnan, KRR, McDonald, WM, Escalona, PR, Doraiswamy, PM, Na, C, Husain, MM, Figiel, GS, Boyko, OB, Ellinwood, EH & Nemeroff, CB 1992, 'Magnetic resonance imaging of the caudate nuclei in depression: Preliminary observations', Archives of General Psychiatry, vol. 49, no. 7, pp. 553-557.
Krishnan KRR, McDonald WM, Escalona PR, Doraiswamy PM, Na C, Husain MM et al. Magnetic resonance imaging of the caudate nuclei in depression: Preliminary observations. Archives of General Psychiatry. 1992;49(7):553-557.
Krishnan, K. Ranga Rama ; McDonald, William M. ; Escalona, P. Rodrigo ; Doraiswamy, P. Murali ; Na, Chul ; Husain, Mustafa M. ; Figiel, Gary S. ; Boyko, Orest B. ; Ellinwood, Everett H. ; Nemeroff, Charles B. / Magnetic resonance imaging of the caudate nuclei in depression : Preliminary observations. In: Archives of General Psychiatry. 1992 ; Vol. 49, No. 7. pp. 553-557.
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