Magnetic resonance myocardial fiber-orientation mapping with direct histological correlation

E. W. Hsu, A. L. Muzikant, S. A. Matulevicius, R. C. Penland, C. S. Henriquez

Research output: Contribution to journalArticle

Abstract

Functional properties of the myocardium are mediated by the tissue structure. Consequently, proper physiological studies and modeling necessitate a precise knowledge of the fiber orientation. Magnetic resonance (MR) diffusion tensor imaging techniques have been used as a nondestructive means to characterize tissue fiber structure; however, the descriptions so far have been mostly qualitative. This study presents a direct, quantitative comparison of high-resolution MR fiber mapping and histology measurements in a block of excised canine myocardium. Results show an excellent correspondence of the measured fiber angles not only on a point-by-point basis (average difference of -2.30 ± 0.98°, n = 239) but also in the transmural rotation of the helix angles (average correlation coefficient of 0.942 ± 0.008 with average false-positive probability of 0.004 ± 0.001, n = 24). These data strongly support the hypothesis that the eigenvector of the largest MR diffusion tensor eigenvalue coincides with the orientation of the local myocardial fibers and underscore the potential of MR imaging as a noninvasive, three-dimensional modality to characterize tissue fiber architecture.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume43
Issue number5
StatePublished - May 1998

Fingerprint

Magnetic Resonance Spectroscopy
Myocardium
Diffusion Tensor Imaging
Canidae
Histology
Magnetic Resonance Imaging

Keywords

  • Anisotropic diffusion
  • Diffusion tensor
  • Magnetic resonance imaging

ASJC Scopus subject areas

  • Physiology

Cite this

Magnetic resonance myocardial fiber-orientation mapping with direct histological correlation. / Hsu, E. W.; Muzikant, A. L.; Matulevicius, S. A.; Penland, R. C.; Henriquez, C. S.

In: American Journal of Physiology - Heart and Circulatory Physiology, Vol. 43, No. 5, 05.1998.

Research output: Contribution to journalArticle

@article{ba126c74abe241c4a27ac0102c1f16c8,
title = "Magnetic resonance myocardial fiber-orientation mapping with direct histological correlation",
abstract = "Functional properties of the myocardium are mediated by the tissue structure. Consequently, proper physiological studies and modeling necessitate a precise knowledge of the fiber orientation. Magnetic resonance (MR) diffusion tensor imaging techniques have been used as a nondestructive means to characterize tissue fiber structure; however, the descriptions so far have been mostly qualitative. This study presents a direct, quantitative comparison of high-resolution MR fiber mapping and histology measurements in a block of excised canine myocardium. Results show an excellent correspondence of the measured fiber angles not only on a point-by-point basis (average difference of -2.30 ± 0.98°, n = 239) but also in the transmural rotation of the helix angles (average correlation coefficient of 0.942 ± 0.008 with average false-positive probability of 0.004 ± 0.001, n = 24). These data strongly support the hypothesis that the eigenvector of the largest MR diffusion tensor eigenvalue coincides with the orientation of the local myocardial fibers and underscore the potential of MR imaging as a noninvasive, three-dimensional modality to characterize tissue fiber architecture.",
keywords = "Anisotropic diffusion, Diffusion tensor, Magnetic resonance imaging",
author = "Hsu, {E. W.} and Muzikant, {A. L.} and Matulevicius, {S. A.} and Penland, {R. C.} and Henriquez, {C. S.}",
year = "1998",
month = "5",
language = "English (US)",
volume = "43",
journal = "American Journal of Physiology - Heart and Circulatory Physiology",
issn = "0363-6135",
publisher = "American Physiological Society",
number = "5",

}

TY - JOUR

T1 - Magnetic resonance myocardial fiber-orientation mapping with direct histological correlation

AU - Hsu, E. W.

AU - Muzikant, A. L.

AU - Matulevicius, S. A.

AU - Penland, R. C.

AU - Henriquez, C. S.

PY - 1998/5

Y1 - 1998/5

N2 - Functional properties of the myocardium are mediated by the tissue structure. Consequently, proper physiological studies and modeling necessitate a precise knowledge of the fiber orientation. Magnetic resonance (MR) diffusion tensor imaging techniques have been used as a nondestructive means to characterize tissue fiber structure; however, the descriptions so far have been mostly qualitative. This study presents a direct, quantitative comparison of high-resolution MR fiber mapping and histology measurements in a block of excised canine myocardium. Results show an excellent correspondence of the measured fiber angles not only on a point-by-point basis (average difference of -2.30 ± 0.98°, n = 239) but also in the transmural rotation of the helix angles (average correlation coefficient of 0.942 ± 0.008 with average false-positive probability of 0.004 ± 0.001, n = 24). These data strongly support the hypothesis that the eigenvector of the largest MR diffusion tensor eigenvalue coincides with the orientation of the local myocardial fibers and underscore the potential of MR imaging as a noninvasive, three-dimensional modality to characterize tissue fiber architecture.

AB - Functional properties of the myocardium are mediated by the tissue structure. Consequently, proper physiological studies and modeling necessitate a precise knowledge of the fiber orientation. Magnetic resonance (MR) diffusion tensor imaging techniques have been used as a nondestructive means to characterize tissue fiber structure; however, the descriptions so far have been mostly qualitative. This study presents a direct, quantitative comparison of high-resolution MR fiber mapping and histology measurements in a block of excised canine myocardium. Results show an excellent correspondence of the measured fiber angles not only on a point-by-point basis (average difference of -2.30 ± 0.98°, n = 239) but also in the transmural rotation of the helix angles (average correlation coefficient of 0.942 ± 0.008 with average false-positive probability of 0.004 ± 0.001, n = 24). These data strongly support the hypothesis that the eigenvector of the largest MR diffusion tensor eigenvalue coincides with the orientation of the local myocardial fibers and underscore the potential of MR imaging as a noninvasive, three-dimensional modality to characterize tissue fiber architecture.

KW - Anisotropic diffusion

KW - Diffusion tensor

KW - Magnetic resonance imaging

UR - http://www.scopus.com/inward/record.url?scp=33750834261&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33750834261&partnerID=8YFLogxK

M3 - Article

VL - 43

JO - American Journal of Physiology - Heart and Circulatory Physiology

JF - American Journal of Physiology - Heart and Circulatory Physiology

SN - 0363-6135

IS - 5

ER -