Magnetite-loaded polymeric micelles as ultrasensitive magnetic-resonance probes

Hua Ai, Christopher Flask, Brent Weinberg, Xintao Shuai, Many D. Pagel, David Farrell, Jeffrey Duerk, Jinming Gao

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Abstract

The development of super-paramagnetic polymer micelles as a new class of magnetic resonance imaging (MRI) probes with high spin-spin relaxivity and sensitivity, was reported. The micelles consists of a cluster of hydrophobic magnetite particles encapsulated inside the hydrophobic core of polymeric micelle whose surface is stabilized by a poly(ethylene glycol) (PEG) shell. The unique core-shell composite design helps to achieve an ultrasensitive MRI detection limit of 5.2 μgmL-1, and promises for an application in molecular imaging and image-visible drug delivery applications. An amphiphilic diblock copolymer of poly(η-caprolactone)-b-polyethylene glycol was used in the study.

Original languageEnglish (US)
Pages (from-to)1949-1952
Number of pages4
JournalAdvanced Materials
Volume17
Issue number16
DOIs
Publication statusPublished - Aug 18 2005

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ASJC Scopus subject areas

  • Materials Science(all)

Cite this

Ai, H., Flask, C., Weinberg, B., Shuai, X., Pagel, M. D., Farrell, D., ... Gao, J. (2005). Magnetite-loaded polymeric micelles as ultrasensitive magnetic-resonance probes. Advanced Materials, 17(16), 1949-1952. https://doi.org/10.1002/adma.200401904