Magneto-therapeutic functionalized carbon nanoparticles for interrogative medicine

Vishal Kapadia, Houjin Huang, Erik Pierstorff, Mark Chen, Dean Ho

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Magnetic nanoparticles and carbon nanotubes have both attained a large amount of focus due to their versatile properties and numerous applications. Thus, interfacing magnetic nanoparticles with carbon nanotubes would generate a class of functional materials with broad potential towards nanoscale medicine. Here, a novel method is discussed of incorporating magnetic nanoparticles (iron oxides) onto carbon nanotubes (IONs+CNTs) as well as applying these IONs+CNTs as therapeutic strategies to promote targeted necrosis in cells which may be relevant towards directed cancer therapy, as well as antibacterial/viral applications. To determine the applicability of the IONs + CNTs, we investigated their effects on the expression of cytokines that regulate cellular stress and inflammation from in vitro RAW 264.7 macrophage cell line growth with the IONs + CNTs. In addition, we performed several characterization trials to confirm the presence of a IONs+CNTs interfacing including infrared spectroscopy and scanning electron microscopy. Moreover, we evaluated the effects of applying a magnetic field towards cells that internalized the IONs+CNTs through microscopic imagery. Furthermore, we exposed the IONs+CNTs to an external rotating magnetic field to determine its applicability to aid in directed cell death. The materials/applications realized through this study may provide an efficient method of producing IONs as well as a novel method towards directed cell death that could be implemented in both the fundamental and translational fields.

Original languageEnglish (US)
Title of host publication3rd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2008
Pages1119-1123
Number of pages5
DOIs
StatePublished - Sep 1 2008
Externally publishedYes
Event3rd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2008 - Sanya, China
Duration: Jan 6 2008Jan 9 2008

Publication series

Name3rd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS

Conference

Conference3rd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2008
CountryChina
CitySanya
Period1/6/081/9/08

Keywords

  • Carbon nanotubes
  • Iron oxide
  • Magnetic spin
  • Nanotechnology
  • Necrosis
  • Therapeutic nanomaterials
  • Water soluble

ASJC Scopus subject areas

  • Control and Systems Engineering
  • Electrical and Electronic Engineering

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  • Cite this

    Kapadia, V., Huang, H., Pierstorff, E., Chen, M., & Ho, D. (2008). Magneto-therapeutic functionalized carbon nanoparticles for interrogative medicine. In 3rd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2008 (pp. 1119-1123). [4484514] (3rd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS). https://doi.org/10.1109/NEMS.2008.4484514