Magnetoencephalographic localization in pediatric epilepsy surgery: Comparison with invasive intracranial electroencephalography

Berge A. Minassian, Hiroshi Otsubo, Shelly Weiss, Irene Elliott, James T. Rutka, O. Carter Snead

Research output: Contribution to journalArticle

169 Citations (Scopus)

Abstract

The object of this study was to determine the concordance of the anatomical location of interictal magnetoencephalographic (MEG) spike foci with the location of ictal onset zones identified by invasive ictal intracranial electroencephalographic recordings in children undergoing evaluation for epilepsy surgery. MEG was performed in 11 children with intractable, nonlesional, extratemporal, localization-related epilepsy. Subsequently, chronic invasive intracranial electroencephalographic monitoring was performed by using subdural electrodes to localize the ictal onset zone and eloquent cortex. Based on the invasive monitoring data, all children had excision of, or multiple subpial transections through, ictal onset cortex and surrounding irritative zones. In 10 of 11 patients, the anatomical location of the epileptiform discharges as determined by MEG corresponded to the ictal onset zone established by ictal intracranial recordings. In all children, the anatomical location of the somatosensory hand area, determined by functional mapping through the subdural electrode array, was the same as that delineated by MEG. Nine of 11 patients became either seizure-free or had a greater than 90% reduction in seizures after surgery, with a mean follow-up of 24 months. MEG is a powerful and accurate tool in the presurgical evaluation of children with refractory nonlesional extratemporal epilepsy.

Original languageEnglish (US)
Pages (from-to)627-633
Number of pages7
JournalAnnals of Neurology
Volume46
Issue number4
DOIs
StatePublished - Oct 14 1999

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Epilepsy
Stroke
Pediatrics
Electrodes
Seizures
Partial Epilepsy
Electrocorticography
Hand

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Magnetoencephalographic localization in pediatric epilepsy surgery : Comparison with invasive intracranial electroencephalography. / Minassian, Berge A.; Otsubo, Hiroshi; Weiss, Shelly; Elliott, Irene; Rutka, James T.; Snead, O. Carter.

In: Annals of Neurology, Vol. 46, No. 4, 14.10.1999, p. 627-633.

Research output: Contribution to journalArticle

Minassian, Berge A. ; Otsubo, Hiroshi ; Weiss, Shelly ; Elliott, Irene ; Rutka, James T. ; Snead, O. Carter. / Magnetoencephalographic localization in pediatric epilepsy surgery : Comparison with invasive intracranial electroencephalography. In: Annals of Neurology. 1999 ; Vol. 46, No. 4. pp. 627-633.
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